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- W2037721823 abstract "Human embryonic stem cells (hESCs) require specific niches for adhesion, expansion, and lineage-specific differentiation. In this study, we showed that a membrane substrate offers better tissue niches for hESC attachment, spreading, proliferation, and differentiation. The cell doubling time was shortened from 46.3±5.7 h for hESCs grown on solid substrates to 25.6±2.6 h for those on polyester (PE) membrane substrates with pore size of 0.4 μm. In addition, we observed an increase of approximately five- to ninefold of definitive endoderm marker gene expression in hESCs differentiated on PE or polyethylene terephthalate membrane substrates. Global gene expression analysis revealed upregulated expressions of a number of extracellular matrix and cell adhesion molecules in hESCs grown on membrane substrates. Further, an enhanced nuclear translocation of β-catenin was detected in these cells. These observations suggested the augmentation of Wnt signaling in hESCs grown on membrane substrates. These results also demonstrated that a membrane substrate can offer better physicochemical cues for enhancing in vitro hESC attachment, proliferation, and differentiation." @default.
- W2037721823 created "2016-06-24" @default.
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- W2037721823 creator A5048321169 @default.
- W2037721823 creator A5090235041 @default.
- W2037721823 date "2012-07-01" @default.
- W2037721823 modified "2023-09-27" @default.
- W2037721823 title "Porous Membrane Substrates Offer Better Niches to Enhance the Wnt Signaling and Promote Human Embryonic Stem Cell Growth and Differentiation" @default.
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- W2037721823 doi "https://doi.org/10.1089/ten.tea.2011.0474" @default.
- W2037721823 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3397116" @default.
- W2037721823 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22429220" @default.
- W2037721823 hasPublicationYear "2012" @default.
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