FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037730377> ?p ?o ?g. }

• W2037730377 endingPage "1003" @default.
• W2037730377 startingPage "998" @default.
• W2037730377 abstract "Oxidatively generated damage to DNA has been implicated as causing mutations that lead to aging and disease. The one-electron oxidation of normal DNA leads to formation of a nucleobase radical cation that hops through the DNA until it is trapped irreversibly, primarily by reaction at guanine. It has been observed that 5-methylcytosine (Cm) is a mutational “hot-spot”. However, Cm in a Watson-Crick base pair with G is not especially susceptible to oxidatively induced damage. Radical cation hopping is inhibited in duplexes that contain C-A or C-T mispairs, but no reaction is detected at cytosine. In contrast, we find that the one-electron oxidation of DNA that contains Cm-A or Cm-T mispairs results primarily in reaction at Cm even in the presence of GG steps. The reaction at Cm is attributed to proton coupled electron transfer, which provides a relatively low activation barrier path for reaction at 5-methylcytosine. This enhanced reactivity of Cm in mispairs may contribute to the formation of mutational hot spots at Cm." @default.
• W2037730377 created "2016-06-24" @default.
• W2037730377 creator A5046513505 @default.
• W2037730377 creator A5077397613 @default.
• W2037730377 date "2012-06-01" @default.
• W2037730377 modified "2023-10-17" @default.
• W2037730377 title "Oxidatively generated damage to DNA at 5-methylcytosine mispairs" @default.
• W2037730377 cites W1562498242 @default.
• W2037730377 cites W1964377700 @default.
• W2037730377 cites W1967332997 @default.
• W2037730377 cites W1969408680 @default.
• W2037730377 cites W1972040015 @default.
• W2037730377 cites W1980421351 @default.
• W2037730377 cites W1987658864 @default.
• W2037730377 cites W1994424962 @default.
• W2037730377 cites W1997269770 @default.
• W2037730377 cites W1998517881 @default.
• W2037730377 cites W2008807833 @default.
• W2037730377 cites W2014990631 @default.
• W2037730377 cites W2015177898 @default.
• W2037730377 cites W2021297717 @default.
• W2037730377 cites W2022477211 @default.
• W2037730377 cites W2028455697 @default.
• W2037730377 cites W2028964417 @default.
• W2037730377 cites W2029874395 @default.
• W2037730377 cites W2031448213 @default.
• W2037730377 cites W2037937229 @default.
• W2037730377 cites W2038820367 @default.
• W2037730377 cites W2040685858 @default.
• W2037730377 cites W2044437889 @default.
• W2037730377 cites W2046770376 @default.
• W2037730377 cites W2054752346 @default.
• W2037730377 cites W2055644432 @default.
• W2037730377 cites W2064344250 @default.
• W2037730377 cites W2068888525 @default.
• W2037730377 cites W2073126970 @default.
• W2037730377 cites W2073784552 @default.
• W2037730377 cites W2088597480 @default.
• W2037730377 cites W2091201245 @default.
• W2037730377 cites W2093041725 @default.
• W2037730377 cites W2093821031 @default.
• W2037730377 cites W2096508529 @default.
• W2037730377 cites W2127245142 @default.
• W2037730377 cites W2135445369 @default.
• W2037730377 cites W2139620481 @default.
• W2037730377 cites W2148838874 @default.
• W2037730377 cites W2327178091 @default.
• W2037730377 cites W2521536734 @default.
• W2037730377 doi "https://doi.org/10.1039/c2pp05379a" @default.
• W2037730377 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22327601" @default.
• W2037730377 hasPublicationYear "2012" @default.
• W2037730377 type Work @default.
• W2037730377 sameAs 2037730377 @default.
• W2037730377 citedByCount "5" @default.
• W2037730377 countsByYear W20377303772013 @default.
• W2037730377 countsByYear W20377303772014 @default.
• W2037730377 countsByYear W20377303772016 @default.
• W2037730377 crossrefType "journal-article" @default.
• W2037730377 hasAuthorship W2037730377A5046513505 @default.
• W2037730377 hasAuthorship W2037730377A5077397613 @default.
• W2037730377 hasBestOaLocation W20377303771 @default.
• W2037730377 hasConcept C104317684 @default.
• W2037730377 hasConcept C123669783 @default.
• W2037730377 hasConcept C142724271 @default.
• W2037730377 hasConcept C143425029 @default.
• W2037730377 hasConcept C185581394 @default.
• W2037730377 hasConcept C185592680 @default.
• W2037730377 hasConcept C204787440 @default.
• W2037730377 hasConcept C2776023528 @default.
• W2037730377 hasConcept C2776910235 @default.
• W2037730377 hasConcept C2778301229 @default.
• W2037730377 hasConcept C512185932 @default.
• W2037730377 hasConcept C552990157 @default.
• W2037730377 hasConcept C55493867 @default.
• W2037730377 hasConcept C61234307 @default.
• W2037730377 hasConcept C71924100 @default.
• W2037730377 hasConcept C75473681 @default.
• W2037730377 hasConceptScore W2037730377C104317684 @default.
• W2037730377 hasConceptScore W2037730377C123669783 @default.
• W2037730377 hasConceptScore W2037730377C142724271 @default.
• W2037730377 hasConceptScore W2037730377C143425029 @default.
• W2037730377 hasConceptScore W2037730377C185581394 @default.
• W2037730377 hasConceptScore W2037730377C185592680 @default.
• W2037730377 hasConceptScore W2037730377C204787440 @default.
• W2037730377 hasConceptScore W2037730377C2776023528 @default.
• W2037730377 hasConceptScore W2037730377C2776910235 @default.
• W2037730377 hasConceptScore W2037730377C2778301229 @default.
• W2037730377 hasConceptScore W2037730377C512185932 @default.
• W2037730377 hasConceptScore W2037730377C552990157 @default.
• W2037730377 hasConceptScore W2037730377C55493867 @default.
• W2037730377 hasConceptScore W2037730377C61234307 @default.
• W2037730377 hasConceptScore W2037730377C71924100 @default.
• W2037730377 hasConceptScore W2037730377C75473681 @default.
• W2037730377 hasIssue "6" @default.
• W2037730377 hasLocation W20377303771 @default.
• W2037730377 hasLocation W20377303772 @default.
• W2037730377 hasOpenAccess W2037730377 @default.
• W2037730377 hasPrimaryLocation W20377303771 @default.

• next