FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037752018> ?p ?o ?g. }

• W2037752018 endingPage "43" @default.
• W2037752018 startingPage "35" @default.
• W2037752018 abstract "Co-administration of ibuprofen (IBU) and isosorbide dinitrate (ISDN) provides synergistic beneficial effects on dystrophic skeletal muscle. Whether this treatment has also cardioprotective effects in this disease was still unknown.To evaluate the effects of co-administration of IBU and ISDN (a) on left ventricular (LV) structure and function, and (b) on cardiac inflammatory response and fibrosis in mdx mice.Three groups of mice were studied: mdx mice treated with IBU (50 mg kg⁻¹)+ISDN (30 mg kg⁻¹) administered daily in the diet, mdx mice that received standard diet without drugs and wild type aged-matched mice. Animals were analysed after 10-11 months of treatment. Structural and functional parameters were evaluated by echocardiography while histological analyses were performed to evaluate inflammatory response, collagen deposition, cardiomyocyte number and area.Treatment for 10-11 months with IBU+ISDN preserved LV wall thickness and LV mass. Drug treatment also preserved the total number of cardiomyocytes in the LV and attenuated the increase in cardiomyocyte size, when compared to untreated mdx mice. Moreover, a trend towards a decreased number of inflammatory cells, a reduced LV myocardial interstitial fibrosis and an enhanced global LV function response to stress was observed in treated mdx mice.Treatment for 10-11 months with IBU+ISDN is effective in preventing the alterations in LV morphology of mdx mice while not reaching statistical significance on LV function and cardiac inflammation." @default.
• W2037752018 created "2016-06-24" @default.
• W2037752018 creator A5010848776 @default.
• W2037752018 creator A5019801772 @default.
• W2037752018 creator A5022573484 @default.
• W2037752018 creator A5027518592 @default.
• W2037752018 creator A5029374004 @default.
• W2037752018 creator A5030506441 @default.
• W2037752018 creator A5043885870 @default.
• W2037752018 creator A5045436115 @default.
• W2037752018 creator A5054522059 @default.
• W2037752018 creator A5074943446 @default.
• W2037752018 date "2013-07-01" @default.
• W2037752018 modified "2023-10-18" @default.
• W2037752018 title "Ibuprofen plus isosorbide dinitrate treatment in the mdx mice ameliorates dystrophic heart structure" @default.
• W2037752018 cites W1514670900 @default.
• W2037752018 cites W1526370806 @default.
• W2037752018 cites W1966493859 @default.
• W2037752018 cites W1979241380 @default.
• W2037752018 cites W1985183676 @default.
• W2037752018 cites W1986203389 @default.
• W2037752018 cites W1994505439 @default.
• W2037752018 cites W1998118119 @default.
• W2037752018 cites W2000294371 @default.
• W2037752018 cites W2002469842 @default.
• W2037752018 cites W2007174173 @default.
• W2037752018 cites W2008403762 @default.
• W2037752018 cites W2013331205 @default.
• W2037752018 cites W2014714895 @default.
• W2037752018 cites W2018567399 @default.
• W2037752018 cites W2022120085 @default.
• W2037752018 cites W2022570317 @default.
• W2037752018 cites W2024466873 @default.
• W2037752018 cites W2031789342 @default.
• W2037752018 cites W2049453660 @default.
• W2037752018 cites W2050860068 @default.
• W2037752018 cites W2051741101 @default.
• W2037752018 cites W2054189227 @default.
• W2037752018 cites W2055314561 @default.
• W2037752018 cites W2055502077 @default.
• W2037752018 cites W2058553583 @default.
• W2037752018 cites W2061963197 @default.
• W2037752018 cites W2065102239 @default.
• W2037752018 cites W2068624628 @default.
• W2037752018 cites W2068984983 @default.
• W2037752018 cites W2069173490 @default.
• W2037752018 cites W2073242943 @default.
• W2037752018 cites W2075361715 @default.
• W2037752018 cites W2078192980 @default.
• W2037752018 cites W2083756165 @default.
• W2037752018 cites W2088541996 @default.
• W2037752018 cites W2088575875 @default.
• W2037752018 cites W2096286415 @default.
• W2037752018 cites W2103597137 @default.
• W2037752018 cites W2108486099 @default.
• W2037752018 cites W2126541517 @default.
• W2037752018 cites W2136089239 @default.
• W2037752018 cites W2136918383 @default.
• W2037752018 cites W2142590785 @default.
• W2037752018 cites W2146168670 @default.
• W2037752018 cites W2146262807 @default.
• W2037752018 cites W2146578470 @default.
• W2037752018 cites W2151419680 @default.
• W2037752018 cites W2153347240 @default.
• W2037752018 cites W2154041187 @default.
• W2037752018 cites W2163318181 @default.
• W2037752018 cites W2165274786 @default.
• W2037752018 cites W2168504323 @default.
• W2037752018 cites W2171146027 @default.
• W2037752018 cites W2331062146 @default.
• W2037752018 cites W2990123797 @default.
• W2037752018 doi "https://doi.org/10.1016/j.phrs.2013.04.009" @default.
• W2037752018 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23644256" @default.
• W2037752018 hasPublicationYear "2013" @default.
• W2037752018 type Work @default.
• W2037752018 sameAs 2037752018 @default.
• W2037752018 citedByCount "22" @default.
• W2037752018 countsByYear W20377520182013 @default.
• W2037752018 countsByYear W20377520182014 @default.
• W2037752018 countsByYear W20377520182015 @default.
• W2037752018 countsByYear W20377520182016 @default.
• W2037752018 countsByYear W20377520182017 @default.
• W2037752018 countsByYear W20377520182019 @default.
• W2037752018 countsByYear W20377520182020 @default.
• W2037752018 countsByYear W20377520182021 @default.
• W2037752018 countsByYear W20377520182023 @default.
• W2037752018 crossrefType "journal-article" @default.
• W2037752018 hasAuthorship W2037752018A5010848776 @default.
• W2037752018 hasAuthorship W2037752018A5019801772 @default.
• W2037752018 hasAuthorship W2037752018A5022573484 @default.
• W2037752018 hasAuthorship W2037752018A5027518592 @default.
• W2037752018 hasAuthorship W2037752018A5029374004 @default.
• W2037752018 hasAuthorship W2037752018A5030506441 @default.
• W2037752018 hasAuthorship W2037752018A5043885870 @default.
• W2037752018 hasAuthorship W2037752018A5045436115 @default.
• W2037752018 hasAuthorship W2037752018A5054522059 @default.
• W2037752018 hasAuthorship W2037752018A5074943446 @default.
• W2037752018 hasBestOaLocation W20377520182 @default.

• next