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- W2037754714 abstract "We report synthesis, in vitro antiviral activity, and stability studies in biological media of original boranophosphonate isosteres of AZT and d4T monophophates. A convenient route for the synthesis of 3'-Azido-3'-deoxythymidine-5'-boranophosphonate 8 and 2',3'-Didehydro-3'-dideoxythymidine-5'-boranophosphonate 12 is described. H-phosphinates 7 and 11, and alpha-boranophosphonates 8 and 12 exhibited no significant in vitro activity against HIV-infected cells, neither against a broad panel of viruses, up to 200 microM. The absence of activity of target compounds 8 and 12 can be partially explained by their short half-life in culture medium." @default.
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- W2037754714 date "2010-02-01" @default.
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- W2037754714 title "Synthesis and antiviral activity of boranophosphonate isosteres of AZT and d4T monophosphates" @default.
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- W2037754714 doi "https://doi.org/10.1016/j.ejmech.2009.11.012" @default.
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