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- W2037755757 abstract "Abstract Oligonucleotide microarray has become one of the most powerful tools in the areas such as genotyping, gene expression, and SNPs detection. However quality control is critical for rapid development of this technology. Several approaches have been attempted to monitor the fabrication steps from oligonucleotide probe printing to data analysis. Yet, quality control methods for presynthesized oligonucleotide probes have not been available. Here we propose a novel approach for the control of the quality of oligonucleotide probes using the technology of denaturing high-performance liquid chromatography (DHPLC). In this work, all possibly existing types of poorly synthesized oligonucleotide probes prepared by artificial method were used to validate the discriminating ability of DHPLC. It was found that DHPLC can not only provide the purity ratio of the oligonucleotide probes accurately, but also detect misincorporation of chemicals in the oligonucleotides such as one base substitution, one base deletion,..." @default.
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- W2037755757 date "2003-01-07" @default.
- W2037755757 modified "2023-10-16" @default.
- W2037755757 title "A Novel Approach for Quality Control of Oligonucleotide Probes Using DHPLC" @default.
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- W2037755757 doi "https://doi.org/10.1081/al-120021529" @default.
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