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- W2037757758 abstract "House dust mite antigen is a well-known allergen in the pathogenesis of atopic dermatitis (AD), a chronic relapsing inflammatory skin disease. We evaluated the AD model mice sensitized with house dust mite antigen and observed a Th2-dominant immune response. In this experiment, BALB/c mice were sensitized percutaneously with house dust mite antigen three times with 7 days interval after skin barrier disruption. A remarkable infiltration of polymorphonuclear granulocytes and monocytes in the cutis was observed in mice treated with this antigen, high serum IgE levels and IL-4 mRNA expression in local lymph node cells was also observed. CD19+ B cell numbers overturned to CD4+ helper T cells. In these mice, there was significant increase of B7.2 (CD86) expression on CD19+ B cells. These results indicate that house dust mite antigen sensitizes BALB/c mice and skews their Th1/Th2 balance toward Th2." @default.
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- W2037757758 date "2003-01-01" @default.
- W2037757758 modified "2023-10-17" @default.
- W2037757758 title "Enhanced expression of B7.2 (CD86) by percutaneous sensitization with house dust mite antigen" @default.
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- W2037757758 doi "https://doi.org/10.1016/s0165-2478(02)00196-7" @default.
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