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- W2037757788 abstract "Fifty-six patients with enterococcal endocarditis received 4 weeks of antimicrobial therapy with penicillin G and streptomycin (36 patients) or, if infections were streptomycin resistant, penicillin and gentamicin (20 patients). Compared with patients who had symptoms for less than 3 months, patients with symptoms for more than 3 months had a higher relapse rate (0% versus 44%; p < 0.001) and mortality (2.5% versus 25%; p < 0.001). Patients with mitral valve endocarditis had a significantly higher relapse rate (25%) than patients with aortic valve infections (0%) (p < 0.01). Gentamicin-associated nephrotoxicity was more frequent (p < 0.001) among patients treated with greater than 3 mg/kg d of gentamicin than among those treated with 3 mg or less (100% versus 20%). Relapse and mortality rates did not differ significantly between patients treated with low-dose or high-dose gentamicin regimens. Patients who have had symptoms of enterococcal endocarditis for more than 3 months or patients with mitral valve infection should receive at least 6 weeks of antimicrobial therapy, but patients without these high-risk factors can be treated for 4 weeks." @default.
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- W2037757788 date "1984-06-01" @default.
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- W2037757788 title "Treatment of Streptomycin-Susceptible and Streptomycin-Resistant Enterococcal Endocarditis" @default.
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- W2037757788 doi "https://doi.org/10.7326/0003-4819-100-6-816" @default.
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