FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037758170> ?p ?o ?g. }

• W2037758170 endingPage "638" @default.
• W2037758170 startingPage "629" @default.
• W2037758170 abstract "A green fluorescent protein (GFP)-Raf-1 fusion protein was used to show that Bcl-2 can target this kinase to mitochondria. Active Raf-1 fused with targeting sequences from an outer mitochondrial membrane protein protected cells from apoptosis and resulted in phosphorylation of BAD, a proapoptotic Bcl-2 homolog. Plasma membrane-targeted Raf-1 did not protect from apoptosis and resulted in phosphorylation of ERK-1 and ERK-2. Untargeted active Raf-1 improved Bcl-2-mediated resistance to apoptosis, whereas a kinase-inactive Raf-1 mutant abrogated apoptosis suppression by Bcl-2. Bcl-2 can therefore target Raf-1 to mitochondrial membranes, allowing this kinase to phosphorylate BAD or possibly other protein substrates involved in apoptosis regulation." @default.
• W2037758170 created "2016-06-24" @default.
• W2037758170 creator A5001270756 @default.
• W2037758170 creator A5025430347 @default.
• W2037758170 creator A5059438505 @default.
• W2037758170 date "1996-11-01" @default.
• W2037758170 modified "2023-10-12" @default.
• W2037758170 title "Bcl-2 Targets the Protein Kinase Raf-1 to Mitochondria" @default.
• W2037758170 cites W127569585 @default.
• W2037758170 cites W1522731616 @default.
• W2037758170 cites W1542447612 @default.
• W2037758170 cites W1557371306 @default.
• W2037758170 cites W1598875578 @default.
• W2037758170 cites W1628370182 @default.
• W2037758170 cites W1675086682 @default.
• W2037758170 cites W1964826110 @default.
• W2037758170 cites W1965069029 @default.
• W2037758170 cites W1965217295 @default.
• W2037758170 cites W1968401207 @default.
• W2037758170 cites W1971571944 @default.
• W2037758170 cites W1973073454 @default.
• W2037758170 cites W1983501834 @default.
• W2037758170 cites W1986388339 @default.
• W2037758170 cites W1991760443 @default.
• W2037758170 cites W1994803892 @default.
• W2037758170 cites W1997208169 @default.
• W2037758170 cites W2000421661 @default.
• W2037758170 cites W2019572526 @default.
• W2037758170 cites W2019687915 @default.
• W2037758170 cites W2020721942 @default.
• W2037758170 cites W2037473273 @default.
• W2037758170 cites W2042917581 @default.
• W2037758170 cites W2051219590 @default.
• W2037758170 cites W2057126981 @default.
• W2037758170 cites W2061920396 @default.
• W2037758170 cites W2068032848 @default.
• W2037758170 cites W2069326426 @default.
• W2037758170 cites W2080889643 @default.
• W2037758170 cites W2095800180 @default.
• W2037758170 cites W2106697922 @default.
• W2037758170 cites W2117669008 @default.
• W2037758170 cites W2134979684 @default.
• W2037758170 cites W2148582802 @default.
• W2037758170 cites W2149967205 @default.
• W2037758170 cites W2154346380 @default.
• W2037758170 cites W2162522735 @default.
• W2037758170 cites W2166785288 @default.
• W2037758170 cites W2167962847 @default.
• W2037758170 cites W2171569176 @default.
• W2037758170 cites W2188651990 @default.
• W2037758170 cites W2282355535 @default.
• W2037758170 doi "https://doi.org/10.1016/s0092-8674(00)81383-5" @default.
• W2037758170 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8929532" @default.
• W2037758170 hasPublicationYear "1996" @default.
• W2037758170 type Work @default.
• W2037758170 sameAs 2037758170 @default.
• W2037758170 citedByCount "750" @default.
• W2037758170 countsByYear W20377581702012 @default.
• W2037758170 countsByYear W20377581702013 @default.
• W2037758170 countsByYear W20377581702014 @default.
• W2037758170 countsByYear W20377581702015 @default.
• W2037758170 countsByYear W20377581702016 @default.
• W2037758170 countsByYear W20377581702017 @default.
• W2037758170 countsByYear W20377581702018 @default.
• W2037758170 countsByYear W20377581702019 @default.
• W2037758170 countsByYear W20377581702020 @default.
• W2037758170 countsByYear W20377581702021 @default.
• W2037758170 countsByYear W20377581702022 @default.
• W2037758170 countsByYear W20377581702023 @default.
• W2037758170 crossrefType "journal-article" @default.
• W2037758170 hasAuthorship W2037758170A5001270756 @default.
• W2037758170 hasAuthorship W2037758170A5025430347 @default.
• W2037758170 hasAuthorship W2037758170A5059438505 @default.
• W2037758170 hasBestOaLocation W20377581701 @default.
• W2037758170 hasConcept C104317684 @default.
• W2037758170 hasConcept C11960822 @default.
• W2037758170 hasConcept C123894998 @default.
• W2037758170 hasConcept C153911025 @default.
• W2037758170 hasConcept C184235292 @default.
• W2037758170 hasConcept C190283241 @default.
• W2037758170 hasConcept C28859421 @default.
• W2037758170 hasConcept C40767141 @default.
• W2037758170 hasConcept C55493867 @default.
• W2037758170 hasConcept C86803240 @default.
• W2037758170 hasConcept C95444343 @default.
• W2037758170 hasConcept C97029542 @default.
• W2037758170 hasConceptScore W2037758170C104317684 @default.
• W2037758170 hasConceptScore W2037758170C11960822 @default.
• W2037758170 hasConceptScore W2037758170C123894998 @default.
• W2037758170 hasConceptScore W2037758170C153911025 @default.
• W2037758170 hasConceptScore W2037758170C184235292 @default.
• W2037758170 hasConceptScore W2037758170C190283241 @default.
• W2037758170 hasConceptScore W2037758170C28859421 @default.
• W2037758170 hasConceptScore W2037758170C40767141 @default.
• W2037758170 hasConceptScore W2037758170C55493867 @default.
• W2037758170 hasConceptScore W2037758170C86803240 @default.
• W2037758170 hasConceptScore W2037758170C95444343 @default.
• W2037758170 hasConceptScore W2037758170C97029542 @default.

• next