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- W2037758314 abstract "The pathology of Alzheimer's disease (AD) features amyloid β peptide deposition, intracellular neurofibrillary tangles and deficits in the cholinergic pathway. Abnormal blood pressure is recognised as a risk factor for the development of AD, although the underlying mechanisms remain unproven. This review proposes angiotensins and associated enzymatic pathways as important mediators of recognised but undefined links between blood pressure and AD. Evidence in support of this involvement translates consistently from the most basic in vitro, in vivo and ex vivo experimental paradigms to more complex human-based observational and experimental studies, which also fortunately offer potential for therapeutic interventions against AD." @default.
- W2037758314 created "2016-06-24" @default.
- W2037758314 creator A5027119794 @default.
- W2037758314 date "2009-01-01" @default.
- W2037758314 modified "2023-10-14" @default.
- W2037758314 title "Angiotensins and Alzheimer's disease: a bench to bedside overview" @default.
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- W2037758314 doi "https://doi.org/10.1186/alzrt3" @default.
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