FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037758741> ?p ?o ?g. }

• W2037758741 abstract "Abstract Background The maintenance of Borrelia burgdorferi in its complex tick-mammalian enzootic life cycle is dependent on the organism's adaptation to its diverse niches. To this end, the RpoN-RpoS regulatory pathway in B. burgdorferi plays a central role in microbial survival and Lyme disease pathogenesis by up- or down-regulating the expression of a number of virulence-associated outer membrane lipoproteins in response to key environmental stimuli. Whereas a number of studies have reported on the expression of RpoS and its target genes, a more comprehensive understanding of when activation of the RpoN-RpoS pathway occurs, and when induction of the pathway is most relevant to specific stage(s) in the life cycle of B. burgdorferi , has been lacking. Results Herein, we examined the expression of rpoS and key lipoprotein genes regulated by RpoS, including ospC , ospA , and dbpA , throughout the entire tick-mammal infectious cycle of B. burgdorferi . Our data revealed that transcription of rpoS , ospC , and dbpA is highly induced in nymphal ticks when taking a blood meal. The RpoN-RpoS pathway remains active during the mammalian infection phase, as indicated by the sustained transcription of rpoS and dbpA in B. burgdorferi within mouse tissues following borrelial dissemination. However, dbpA transcription levels in fed larvae and intermolt larvae suggested that an additional layer of control likely is involved in the expression of the dbpBA operon. Our results also provide further evidence for the downregulation of ospA expression during mammalian infection, and the repression of ospC at later phases of mammalian infection by B. burgdorferi . Conclusion Our study demonstrates that the RpoN-RpoS regulatory pathway is initially activated during the tick transmission of B. burgdorferi to its mammalian host, and is sustained during mammalian infection." @default.
• W2037758741 created "2016-06-24" @default.
• W2037758741 creator A5010290220 @default.
• W2037758741 creator A5013807126 @default.
• W2037758741 creator A5014474723 @default.
• W2037758741 creator A5022173812 @default.
• W2037758741 creator A5029965824 @default.
• W2037758741 creator A5052457700 @default.
• W2037758741 creator A5059747463 @default.
• W2037758741 date "2012-03-23" @default.
• W2037758741 modified "2023-09-27" @default.
• W2037758741 title "Activation of the RpoN-RpoS regulatory pathway during the enzootic life cycle of Borrelia burgdorferi" @default.
• W2037758741 cites W1550355855 @default.
• W2037758741 cites W1557420229 @default.
• W2037758741 cites W1645200692 @default.
• W2037758741 cites W1911163705 @default.
• W2037758741 cites W1937263263 @default.
• W2037758741 cites W1946717434 @default.
• W2037758741 cites W1964539548 @default.
• W2037758741 cites W1966486525 @default.
• W2037758741 cites W1968937321 @default.
• W2037758741 cites W1977904572 @default.
• W2037758741 cites W1983580481 @default.
• W2037758741 cites W1983831412 @default.
• W2037758741 cites W1986984168 @default.
• W2037758741 cites W1999567714 @default.
• W2037758741 cites W2017047316 @default.
• W2037758741 cites W2019962465 @default.
• W2037758741 cites W2026635761 @default.
• W2037758741 cites W2037310526 @default.
• W2037758741 cites W2043454090 @default.
• W2037758741 cites W2047283050 @default.
• W2037758741 cites W2049296526 @default.
• W2037758741 cites W2062364913 @default.
• W2037758741 cites W2063367477 @default.
• W2037758741 cites W2067408716 @default.
• W2037758741 cites W2069127412 @default.
• W2037758741 cites W2070874919 @default.
• W2037758741 cites W2074454643 @default.
• W2037758741 cites W2075321830 @default.
• W2037758741 cites W2076096086 @default.
• W2037758741 cites W2083663976 @default.
• W2037758741 cites W2086884639 @default.
• W2037758741 cites W2090093881 @default.
• W2037758741 cites W2093538084 @default.
• W2037758741 cites W2106061533 @default.
• W2037758741 cites W2111489112 @default.
• W2037758741 cites W2111701441 @default.
• W2037758741 cites W2112984193 @default.
• W2037758741 cites W2114898485 @default.
• W2037758741 cites W2121072694 @default.
• W2037758741 cites W2121386707 @default.
• W2037758741 cites W2121426156 @default.
• W2037758741 cites W2123757128 @default.
• W2037758741 cites W2125366409 @default.
• W2037758741 cites W2126830973 @default.
• W2037758741 cites W2131095051 @default.
• W2037758741 cites W2134259286 @default.
• W2037758741 cites W2135278450 @default.
• W2037758741 cites W2135605184 @default.
• W2037758741 cites W2136252131 @default.
• W2037758741 cites W2138961431 @default.
• W2037758741 cites W2139147444 @default.
• W2037758741 cites W2139262548 @default.
• W2037758741 cites W2140704881 @default.
• W2037758741 cites W2141059784 @default.
• W2037758741 cites W2142117803 @default.
• W2037758741 cites W2145741346 @default.
• W2037758741 cites W2151239002 @default.
• W2037758741 cites W2157570019 @default.
• W2037758741 cites W2157620368 @default.
• W2037758741 cites W2159609005 @default.
• W2037758741 cites W2160144985 @default.
• W2037758741 cites W2160324322 @default.
• W2037758741 cites W2160953240 @default.
• W2037758741 cites W2162608393 @default.
• W2037758741 cites W2163299388 @default.
• W2037758741 cites W2163821635 @default.
• W2037758741 cites W2165013640 @default.
• W2037758741 cites W2166361383 @default.
• W2037758741 cites W2166799325 @default.
• W2037758741 cites W2167998914 @default.
• W2037758741 cites W4229726285 @default.
• W2037758741 doi "https://doi.org/10.1186/1471-2180-12-44" @default.
• W2037758741 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3320556" @default.
• W2037758741 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22443136" @default.
• W2037758741 hasPublicationYear "2012" @default.
• W2037758741 type Work @default.
• W2037758741 sameAs 2037758741 @default.
• W2037758741 citedByCount "57" @default.
• W2037758741 countsByYear W20377587412012 @default.
• W2037758741 countsByYear W20377587412013 @default.
• W2037758741 countsByYear W20377587412014 @default.
• W2037758741 countsByYear W20377587412015 @default.
• W2037758741 countsByYear W20377587412016 @default.
• W2037758741 countsByYear W20377587412017 @default.
• W2037758741 countsByYear W20377587412018 @default.
• W2037758741 countsByYear W20377587412019 @default.
• W2037758741 countsByYear W20377587412020 @default.
• W2037758741 countsByYear W20377587412021 @default.

• next