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• W2037759103 abstract "You have accessJournal of UrologySexual Function/Dysfunction/Andrology: Medical and Nonsurgical Therapy1 Apr 20131507 NEUTRALIZING ANTIBODY FOR NERVE INJURY-INDUCED PROTEIN 1 RESTORES ERECTILE FUNCTION THROUGH ENHANCED CAVERNOUS ENDOTHELIAL REGENERATION IN THE STREPTOZOTOCIN-INDUCED DIABETIC MOUSE Ji-Kan Ryu, Guo Nan Yin, Woo Jean Kim, Hai-Rong Jin, Min Ji Choi, Kang-Moon Song, Mi Hye Kwon, Ki-Dong Kwon, Dulguun Batbold, and Jun-Kyu Suh Ji-Kan RyuJi-Kan Ryu Incheon, Korea, Republic of More articles by this author , Guo Nan YinGuo Nan Yin Incheon, Korea, Republic of More articles by this author , Woo Jean KimWoo Jean Kim Incheon, Korea, Republic of More articles by this author , Hai-Rong JinHai-Rong Jin Incheon, Korea, Republic of More articles by this author , Min Ji ChoiMin Ji Choi Incheon, Korea, Republic of More articles by this author , Kang-Moon SongKang-Moon Song Incheon, Korea, Republic of More articles by this author , Mi Hye KwonMi Hye Kwon Incheon, Korea, Republic of More articles by this author , Ki-Dong KwonKi-Dong Kwon Incheon, Korea, Republic of More articles by this author , Dulguun BatboldDulguun Batbold Incheon, Korea, Republic of More articles by this author , and Jun-Kyu SuhJun-Kyu Suh Incheon, Korea, Republic of More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2013.02.2985AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Patients with diabetic erectile dysfunction (ED) often have severe endothelial dysfunction, which results in poor response to oral phosphodiesterase-5 inhibitors. Nerve injury-induced protein 1, Ninjurin-1 (Ninj1) has been known to be up-regulated after peripheral nerve injury and to be related to vascular regression during embryonic period. In the present study, we determined whether and how Ninjurin 1 neutralizing antibody (Ninj1-Ab) restores erectile function in diabetic animals. METHODS Five groups of mice were used: control nondiabetic mice, streptozotocin-induced diabetic mice, and diabetic mice treated with a single intracavernous injection of IgG control antibody or Ninj1-Ab (1.0 μg or 2.5 μg/20 μl, respectively). Two weeks later, erectile function was measured by electrical stimulation of cavernous nerve. The penis was then harvested and stained with hydroethidine or antibodies to PECAM-1, phosphohistone H3, and nitrotyrosine. We performed western blot analysis of angiopoietin-1 (Ang1), angiopoietin-2 (Ang2), Akt, phospho-Akt, eNOS, phospho-eNOS, p47phox, and iNOS. RESULTS Local delivery of Ninj1-Ab significantly increased cavernous endothelial content through enhanced endothelial cell proliferation, and induced phosphorylation of Akt and eNOS compared with that in the untreated or IgG-treated diabetic group. Endothelial protective effects, such as decreased expression of p47phox and inducible NOS, and decrease in the generation of reactive oxygen species including superoxide anion and peroxinitrite, and decrease in the number of apoptotic cells in the cavernous endothelium, was noted in the diabetic mice treated with Ninj1-Ab. The Ang1 expression was down-regulated and Ang2 expression was up-regulated in the diabetic penis compared with that in controls, which was reversed by treatment with Ninj1-Ab. High-dose of Ninj1-Ab (2.5 μg/20 μl) induced profound restoration of erectile function in the diabetic mice (up to 90% of the control values), whereas low-dose of Ninj1-Ab (1 μg/20 μl) elicited partial improvement. CONCLUSIONS Cavernous endothelial regeneration by using Ninj1-Ab is a novel therapeutic strategy for the treatment of vasculogenic ED. © 2013 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 189Issue 4SApril 2013Page: e618 Advertisement Copyright & Permissions© 2013 by American Urological Association Education and Research, Inc.MetricsAuthor Information Ji-Kan Ryu Incheon, Korea, Republic of More articles by this author Guo Nan Yin Incheon, Korea, Republic of More articles by this author Woo Jean Kim Incheon, Korea, Republic of More articles by this author Hai-Rong Jin Incheon, Korea, Republic of More articles by this author Min Ji Choi Incheon, Korea, Republic of More articles by this author Kang-Moon Song Incheon, Korea, Republic of More articles by this author Mi Hye Kwon Incheon, Korea, Republic of More articles by this author Ki-Dong Kwon Incheon, Korea, Republic of More articles by this author Dulguun Batbold Incheon, Korea, Republic of More articles by this author Jun-Kyu Suh Incheon, Korea, Republic of More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ..." @default.
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• W2037759103 title "1507 NEUTRALIZING ANTIBODY FOR NERVE INJURY-INDUCED PROTEIN 1 RESTORES ERECTILE FUNCTION THROUGH ENHANCED CAVERNOUS ENDOTHELIAL REGENERATION IN THE STREPTOZOTOCIN-INDUCED DIABETIC MOUSE" @default.
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