FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037759904> ?p ?o ?g. }

• W2037759904 endingPage "e6424" @default.
• W2037759904 startingPage "e6424" @default.
• W2037759904 abstract "Background Human skin is able to mount a fast response against invading microorganisms by the release of antimicrobial proteins such as the ribonuclease RNase 7. Because RNase 7 exhibits high activity against Enterococcus faecium the aim of this study was to further explore the role of RNase 7 in the cutaneous innate defense system against E. faecium. Methodology/Principal Findings Absolute quantification using real-time PCR and ELISA revealed that primary keratinocytes expressed high levels of RNase 7. Immunohistochemistry showed RNase 7 expression in all epidermal layers of the skin with an intensification in the upper more differentiated layers. Furthermore, RNase 7 was secreted by keratinocytes in vitro and in vivo in a site-dependent way. RNase 7 was still active against E. faecium at low pH (5.5) or high NaCl (150 mM) concentration and the bactericidal activity of RNase 7 against E. faecium required no ribonuclease activity as shown by recombinant RNase 7 lacking enzymatic activity. To further explore the role of RNase 7 in cutaneous defense against E. faecium, we investigated whether RNase 7 contributes to the E. faecium killing activity of skin extracts derived from stratum corneum. Treatment of the skin extract with an RNase 7 specific antibody, which neutralizes the antimicrobial activity of RNase 7, diminished its E. faecium killing activity. Conclusions/Significance Our data indicate that RNase 7 contributes to the E. faecium-killing activity of skin extracts and suggest an important role for RNase 7 in the protection of human skin against E. faecium colonization." @default.
• W2037759904 created "2016-06-24" @default.
• W2037759904 creator A5027713095 @default.
• W2037759904 creator A5062097412 @default.
• W2037759904 creator A5064719549 @default.
• W2037759904 creator A5071684425 @default.
• W2037759904 creator A5074009808 @default.
• W2037759904 creator A5074088715 @default.
• W2037759904 date "2009-07-29" @default.
• W2037759904 modified "2023-10-15" @default.
• W2037759904 title "RNase 7 Contributes to the Cutaneous Defense against Enterococcus faecium" @default.
• W2037759904 cites W1607924481 @default.
• W2037759904 cites W1662030037 @default.
• W2037759904 cites W1732204574 @default.
• W2037759904 cites W1964758221 @default.
• W2037759904 cites W1965004275 @default.
• W2037759904 cites W1977160855 @default.
• W2037759904 cites W1977549713 @default.
• W2037759904 cites W1978194636 @default.
• W2037759904 cites W1978458547 @default.
• W2037759904 cites W1983987058 @default.
• W2037759904 cites W1986881524 @default.
• W2037759904 cites W1987287925 @default.
• W2037759904 cites W1990436439 @default.
• W2037759904 cites W1998995917 @default.
• W2037759904 cites W2001439699 @default.
• W2037759904 cites W2001592155 @default.
• W2037759904 cites W2007121925 @default.
• W2037759904 cites W2020093258 @default.
• W2037759904 cites W2020401787 @default.
• W2037759904 cites W2024758086 @default.
• W2037759904 cites W2031576296 @default.
• W2037759904 cites W2042675697 @default.
• W2037759904 cites W2045741895 @default.
• W2037759904 cites W2046734440 @default.
• W2037759904 cites W2050853668 @default.
• W2037759904 cites W2054602599 @default.
• W2037759904 cites W2059099732 @default.
• W2037759904 cites W2060483617 @default.
• W2037759904 cites W2065273951 @default.
• W2037759904 cites W2065816870 @default.
• W2037759904 cites W2066149033 @default.
• W2037759904 cites W2067131111 @default.
• W2037759904 cites W2068434462 @default.
• W2037759904 cites W2075158987 @default.
• W2037759904 cites W2077604052 @default.
• W2037759904 cites W2080747086 @default.
• W2037759904 cites W2085793178 @default.
• W2037759904 cites W2086928290 @default.
• W2037759904 cites W2089348575 @default.
• W2037759904 cites W2090042814 @default.
• W2037759904 cites W2141934994 @default.
• W2037759904 cites W2150365288 @default.
• W2037759904 doi "https://doi.org/10.1371/journal.pone.0006424" @default.
• W2037759904 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2712763" @default.
• W2037759904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19641608" @default.
• W2037759904 hasPublicationYear "2009" @default.
• W2037759904 type Work @default.
• W2037759904 sameAs 2037759904 @default.
• W2037759904 citedByCount "78" @default.
• W2037759904 countsByYear W20377599042012 @default.
• W2037759904 countsByYear W20377599042013 @default.
• W2037759904 countsByYear W20377599042014 @default.
• W2037759904 countsByYear W20377599042015 @default.
• W2037759904 countsByYear W20377599042016 @default.
• W2037759904 countsByYear W20377599042017 @default.
• W2037759904 countsByYear W20377599042018 @default.
• W2037759904 countsByYear W20377599042019 @default.
• W2037759904 countsByYear W20377599042020 @default.
• W2037759904 countsByYear W20377599042021 @default.
• W2037759904 countsByYear W20377599042022 @default.
• W2037759904 crossrefType "journal-article" @default.
• W2037759904 hasAuthorship W2037759904A5027713095 @default.
• W2037759904 hasAuthorship W2037759904A5062097412 @default.
• W2037759904 hasAuthorship W2037759904A5064719549 @default.
• W2037759904 hasAuthorship W2037759904A5071684425 @default.
• W2037759904 hasAuthorship W2037759904A5074009808 @default.
• W2037759904 hasAuthorship W2037759904A5074088715 @default.
• W2037759904 hasBestOaLocation W20377599041 @default.
• W2037759904 hasConcept C104317684 @default.
• W2037759904 hasConcept C10879258 @default.
• W2037759904 hasConcept C2777677444 @default.
• W2037759904 hasConcept C2778976237 @default.
• W2037759904 hasConcept C501593827 @default.
• W2037759904 hasConcept C55493867 @default.
• W2037759904 hasConcept C67705224 @default.
• W2037759904 hasConcept C86803240 @default.
• W2037759904 hasConcept C89423630 @default.
• W2037759904 hasConceptScore W2037759904C104317684 @default.
• W2037759904 hasConceptScore W2037759904C10879258 @default.
• W2037759904 hasConceptScore W2037759904C2777677444 @default.
• W2037759904 hasConceptScore W2037759904C2778976237 @default.
• W2037759904 hasConceptScore W2037759904C501593827 @default.
• W2037759904 hasConceptScore W2037759904C55493867 @default.
• W2037759904 hasConceptScore W2037759904C67705224 @default.
• W2037759904 hasConceptScore W2037759904C86803240 @default.
• W2037759904 hasConceptScore W2037759904C89423630 @default.
• W2037759904 hasIssue "7" @default.

• next