FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037761260> ?p ?o ?g. }

• W2037761260 endingPage "86" @default.
• W2037761260 startingPage "80" @default.
• W2037761260 abstract "The present study investigated the effect of ebselen (EB) against hyperglycemia induced by the organophosphate (OPI) diazinon (DI) in rats. The insulin-mimetic properties of EB were investigated in vitro with the aim of better understanding the hypoglycemic effect of this compound. The protective effect of EB against pancreatic and hepatic damage caused by DI in rats was also appraised. In the in vivo experiments, rats were pre-treated with a single injection of EB (50 mg/kg, intraperitoneal, i.p.). Afterward, animals were treated with a single injection of DI (200 mg/kg, i.p.). The parameters indicative of pancreatic and hepatic damage such as, serum amylase, lipase, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) activities as well as serum glucose levels, hepatic glycogen content and glucose-6-phosphatase (G6Pase) activity were determined. EB pre-treatment was effective in reducing serum amylase, lipase, AST, ALT, ALP, and LDH activities, protecting against pancreatic and hepatic damage. EB reduced hyperglycemia and increased hepatic glycogen content in animals exposed to DI. In the in vitro assays, EB (150 μM) or insulin (IN 10 μM, positive control) was incubated with either skeletal muscle or hepatic tissue with the aim of measuring glucose uptake, glycogen synthesis and glycogen breakdown. EB increased the glucose uptake in skeletal muscle, stimulated hepatic glycogen synthesis and inhibited glycogen breakdown in a similar way to IN. In conclusion, EB, possibly through its insulin-mimetic action, protected against pancreatic and hepatic damage caused by DI in rats." @default.
• W2037761260 created "2016-06-24" @default.
• W2037761260 creator A5001474047 @default.
• W2037761260 creator A5012650363 @default.
• W2037761260 creator A5024981412 @default.
• W2037761260 creator A5027426583 @default.
• W2037761260 creator A5047304660 @default.
• W2037761260 creator A5074905169 @default.
• W2037761260 date "2012-05-01" @default.
• W2037761260 modified "2023-09-26" @default.
• W2037761260 title "Ebselen reduces hyperglycemia temporarily-induced by diazinon: A compound with insulin-mimetic properties" @default.
• W2037761260 cites W1559914591 @default.
• W2037761260 cites W190847553 @default.
• W2037761260 cites W1967351568 @default.
• W2037761260 cites W1972272933 @default.
• W2037761260 cites W1977095827 @default.
• W2037761260 cites W1990484506 @default.
• W2037761260 cites W1993304927 @default.
• W2037761260 cites W2003565525 @default.
• W2037761260 cites W2004868091 @default.
• W2037761260 cites W2017350513 @default.
• W2037761260 cites W2021051803 @default.
• W2037761260 cites W2029302143 @default.
• W2037761260 cites W2029614402 @default.
• W2037761260 cites W2032717400 @default.
• W2037761260 cites W2038982079 @default.
• W2037761260 cites W2043236541 @default.
• W2037761260 cites W2048122175 @default.
• W2037761260 cites W2054321341 @default.
• W2037761260 cites W2056256579 @default.
• W2037761260 cites W2060290647 @default.
• W2037761260 cites W2061611242 @default.
• W2037761260 cites W2061633343 @default.
• W2037761260 cites W2066191106 @default.
• W2037761260 cites W2067114364 @default.
• W2037761260 cites W2069887268 @default.
• W2037761260 cites W2070450103 @default.
• W2037761260 cites W2073169476 @default.
• W2037761260 cites W2075654139 @default.
• W2037761260 cites W2077408729 @default.
• W2037761260 cites W2112830407 @default.
• W2037761260 cites W2133613922 @default.
• W2037761260 cites W2140992272 @default.
• W2037761260 cites W2147771723 @default.
• W2037761260 cites W2167488213 @default.
• W2037761260 cites W2167580473 @default.
• W2037761260 cites W4293247451 @default.
• W2037761260 doi "https://doi.org/10.1016/j.cbi.2012.03.008" @default.
• W2037761260 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22484362" @default.
• W2037761260 hasPublicationYear "2012" @default.
• W2037761260 type Work @default.
• W2037761260 sameAs 2037761260 @default.
• W2037761260 citedByCount "11" @default.
• W2037761260 countsByYear W20377612602012 @default.
• W2037761260 countsByYear W20377612602014 @default.
• W2037761260 countsByYear W20377612602017 @default.
• W2037761260 countsByYear W20377612602018 @default.
• W2037761260 countsByYear W20377612602019 @default.
• W2037761260 countsByYear W20377612602020 @default.
• W2037761260 countsByYear W20377612602021 @default.
• W2037761260 countsByYear W20377612602022 @default.
• W2037761260 crossrefType "journal-article" @default.
• W2037761260 hasAuthorship W2037761260A5001474047 @default.
• W2037761260 hasAuthorship W2037761260A5012650363 @default.
• W2037761260 hasAuthorship W2037761260A5024981412 @default.
• W2037761260 hasAuthorship W2037761260A5027426583 @default.
• W2037761260 hasAuthorship W2037761260A5047304660 @default.
• W2037761260 hasAuthorship W2037761260A5074905169 @default.
• W2037761260 hasConcept C126322002 @default.
• W2037761260 hasConcept C134018914 @default.
• W2037761260 hasConcept C150903083 @default.
• W2037761260 hasConcept C160160445 @default.
• W2037761260 hasConcept C161176658 @default.
• W2037761260 hasConcept C170835558 @default.
• W2037761260 hasConcept C181199279 @default.
• W2037761260 hasConcept C185592680 @default.
• W2037761260 hasConcept C207001950 @default.
• W2037761260 hasConcept C2777318727 @default.
• W2037761260 hasConcept C2777499176 @default.
• W2037761260 hasConcept C2779306644 @default.
• W2037761260 hasConcept C2779697368 @default.
• W2037761260 hasConcept C2779842916 @default.
• W2037761260 hasConcept C2781005915 @default.
• W2037761260 hasConcept C55493867 @default.
• W2037761260 hasConcept C555293320 @default.
• W2037761260 hasConcept C6557445 @default.
• W2037761260 hasConcept C71924100 @default.
• W2037761260 hasConcept C86803240 @default.
• W2037761260 hasConceptScore W2037761260C126322002 @default.
• W2037761260 hasConceptScore W2037761260C134018914 @default.
• W2037761260 hasConceptScore W2037761260C150903083 @default.
• W2037761260 hasConceptScore W2037761260C160160445 @default.
• W2037761260 hasConceptScore W2037761260C161176658 @default.
• W2037761260 hasConceptScore W2037761260C170835558 @default.
• W2037761260 hasConceptScore W2037761260C181199279 @default.
• W2037761260 hasConceptScore W2037761260C185592680 @default.
• W2037761260 hasConceptScore W2037761260C207001950 @default.
• W2037761260 hasConceptScore W2037761260C2777318727 @default.

• next