FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037761440> ?p ?o ?g. }

• W2037761440 endingPage "208" @default.
• W2037761440 startingPage "201" @default.
• W2037761440 abstract "Angiotensin II (ANG II) is known to be a potent vasoconstrictor agent in the pulmonary circulation. Furthermore, type 1 ANG II receptor blockade with losartan attenuates acute hypoxic pulmonary vasoconstriction in normal subjects. The aim of this study was therefore to evaluate the haemodynamic and endocrine sequelae of type 1 ANG II receptor blockade in patients with hypoxaemic cor pulmonale.Nine patients with chronic obstructive pulmonary disease (COPD) age 67 +/- 3 years with pulmonary hypertension and normal left ventricular systolic function were studied on two separate occasions in a double-blind, placebo-controlled, crossover study. They were randomised to receive either 50 mg of oral losartan or matched placebo. Pulsed wave Doppler echocardiography was used to measure cardiac output (CO), mean pulmonary artery pressure (MPAP) and hence systemic vascular resistance (SVR) and total pulmonary vascular resistance (TPR). Haemodynamic measurements and venous blood samples were taken at baseline and after 2 and 4 h.Maximal effects were observed at 4 h where losartan compared to placebo resulted in a significant reduction in both MPAP (28.6 +/- 2.0 vs 32.4 +/- 1.5 mmHg) and TPR (428 +/- 40 vs 510 +/- dyn.s.cm-5), respectively. Similarly losartan compared to placebo resulted in a significant reduction in MAP (87 +/- 4.5 vs 93 +/- 3.2 mmHg) and SVR (1293 +/- 94 vs 1462 +/- 112 dyn.s.cm-5), and significantly increased CO (5.58 +/- 0.43 vs 5.31 +/- 0.42 l/min). In addition, plasma aldosterone was significantly lower after treatment with losartan compared to placebo: 76 +/- 23 vs 164 +/- 43 pg/ml respectively.Thus, selective type 1 ANG II receptor blockade appears to have beneficial pulmonary and endocrine effects, suggesting a possible therapeutic role in the management of hypoxaemic cor pulmonale." @default.
• W2037761440 created "2016-06-24" @default.
• W2037761440 creator A5011200161 @default.
• W2037761440 creator A5012612698 @default.
• W2037761440 creator A5039778206 @default.
• W2037761440 creator A5054519215 @default.
• W2037761440 creator A5057526566 @default.
• W2037761440 date "1997-01-01" @default.
• W2037761440 modified "2023-10-14" @default.
• W2037761440 title "Haemodynamic and endocrine effects of type 1 angiotensin II receptor blockade in patients with hypoxaemic cor pulmonale" @default.
• W2037761440 cites W1499386201 @default.
• W2037761440 cites W1828497448 @default.
• W2037761440 cites W1856522064 @default.
• W2037761440 cites W1976726808 @default.
• W2037761440 cites W1979981949 @default.
• W2037761440 cites W1984670817 @default.
• W2037761440 cites W1990060127 @default.
• W2037761440 cites W1994586354 @default.
• W2037761440 cites W2000415901 @default.
• W2037761440 cites W2006739286 @default.
• W2037761440 cites W2016686407 @default.
• W2037761440 cites W2025105504 @default.
• W2037761440 cites W2026499651 @default.
• W2037761440 cites W2030669174 @default.
• W2037761440 cites W2038161096 @default.
• W2037761440 cites W2046493995 @default.
• W2037761440 cites W2051868585 @default.
• W2037761440 cites W2063084021 @default.
• W2037761440 cites W2063834587 @default.
• W2037761440 cites W2065175578 @default.
• W2037761440 cites W2069639622 @default.
• W2037761440 cites W2073340048 @default.
• W2037761440 cites W2073684118 @default.
• W2037761440 cites W2076274336 @default.
• W2037761440 cites W2077424034 @default.
• W2037761440 cites W2088871419 @default.
• W2037761440 cites W2094898334 @default.
• W2037761440 cites W2097712021 @default.
• W2037761440 cites W2099601233 @default.
• W2037761440 cites W2112789217 @default.
• W2037761440 cites W2120476977 @default.
• W2037761440 cites W2131397694 @default.
• W2037761440 cites W2142893061 @default.
• W2037761440 cites W2145879452 @default.
• W2037761440 cites W2155014088 @default.
• W2037761440 cites W2202488002 @default.
• W2037761440 cites W2228139916 @default.
• W2037761440 cites W2333913768 @default.
• W2037761440 cites W2345306928 @default.
• W2037761440 cites W2409482928 @default.
• W2037761440 cites W2412781766 @default.
• W2037761440 cites W2415358238 @default.
• W2037761440 cites W2464555459 @default.
• W2037761440 cites W2921228819 @default.
• W2037761440 cites W3101950577 @default.
• W2037761440 cites W3145822552 @default.
• W2037761440 cites W34930438 @default.
• W2037761440 doi "https://doi.org/10.1016/s0008-6363(96)00180-0" @default.
• W2037761440 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9059545" @default.
• W2037761440 hasPublicationYear "1997" @default.
• W2037761440 type Work @default.
• W2037761440 sameAs 2037761440 @default.
• W2037761440 citedByCount "68" @default.
• W2037761440 countsByYear W20377614402012 @default.
• W2037761440 countsByYear W20377614402014 @default.
• W2037761440 countsByYear W20377614402015 @default.
• W2037761440 countsByYear W20377614402017 @default.
• W2037761440 countsByYear W20377614402018 @default.
• W2037761440 countsByYear W20377614402019 @default.
• W2037761440 countsByYear W20377614402020 @default.
• W2037761440 countsByYear W20377614402021 @default.
• W2037761440 countsByYear W20377614402022 @default.
• W2037761440 countsByYear W20377614402023 @default.
• W2037761440 crossrefType "journal-article" @default.
• W2037761440 hasAuthorship W2037761440A5011200161 @default.
• W2037761440 hasAuthorship W2037761440A5012612698 @default.
• W2037761440 hasAuthorship W2037761440A5039778206 @default.
• W2037761440 hasAuthorship W2037761440A5054519215 @default.
• W2037761440 hasAuthorship W2037761440A5057526566 @default.
• W2037761440 hasBestOaLocation W20377614401 @default.
• W2037761440 hasConcept C126322002 @default.
• W2037761440 hasConcept C139940330 @default.
• W2037761440 hasConcept C142724271 @default.
• W2037761440 hasConcept C164705383 @default.
• W2037761440 hasConcept C178853913 @default.
• W2037761440 hasConcept C204787440 @default.
• W2037761440 hasConcept C27081682 @default.
• W2037761440 hasConcept C2778525890 @default.
• W2037761440 hasConcept C2780288358 @default.
• W2037761440 hasConcept C2780930700 @default.
• W2037761440 hasConcept C2780940725 @default.
• W2037761440 hasConcept C2908929049 @default.
• W2037761440 hasConcept C29323129 @default.
• W2037761440 hasConcept C42219234 @default.
• W2037761440 hasConcept C58245268 @default.
• W2037761440 hasConcept C71924100 @default.
• W2037761440 hasConcept C84393581 @default.
• W2037761440 hasConceptScore W2037761440C126322002 @default.

• next