Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037761710> ?p ?o ?g. }
- W2037761710 endingPage "146" @default.
- W2037761710 startingPage "134" @default.
- W2037761710 abstract "N-terminal protein modifications correspond to the first modifications which in principle any protein may undergo, before translation is completed by the ribosome. This class of essential modifications can have different nature or function and be catalyzed by a variety of dedicated enzymes. Here, we review the current state of the major N-terminal co-translational modifications, with a particular emphasis to their catalysts, which belong to metalloprotease and acyltransferase clans. The earliest of these modifications corresponds to the N-terminal methionine excision, an ubiquitous and essential process leading to the removal of the first methionine. N-alpha acetylation occurs also in all Kingdoms although its extent appears to be significantly increased in higher eukaryotes. Finally, N-myristoylation is a crucial pathway existing only in eukaryotes. Recent studies dealing on how some of these co-translational modifiers might work in close vicinity of the ribosome is starting to provide new information on when these modifications exactly take place on the elongating nascent chain and the interplay with other ribosome biogenesis factors taking in charge the nascent chains. Here a comprehensive overview of the recent advances in the field of N-terminal protein modifications is given." @default.
- W2037761710 created "2016-06-24" @default.
- W2037761710 creator A5072337283 @default.
- W2037761710 creator A5072983746 @default.
- W2037761710 creator A5083236007 @default.
- W2037761710 date "2015-07-01" @default.
- W2037761710 modified "2023-10-05" @default.
- W2037761710 title "N-terminal protein modifications: Bringing back into play the ribosome" @default.
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