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• W2037762444 endingPage "2983" @default.
• W2037762444 startingPage "2974" @default.
• W2037762444 abstract "GABA C receptors (GABA C Rs) are widely expressed in the mammalian subcortical visual system, particularly in the retina and superior colliculus (SC). GABA C Rs are composed of specific ρ1–3 subunits the expression of which varies among visual structures. Thus ρ1 subunits are most abundant in retina, and their loss eliminates GABA C R expression and function. In the SC, ρ2 subunit expression may be equal to or stronger than ρ1 subunit expression; however, results across studies vary considerably. To more directly assess the expression of GABA C R subunits, we characterized inhibition in the SC of wild-type (WT) and GABA C ρ1 Null mice that lack expression of GABA C ρ1 subunits. We used whole cell patch-clamp recordings and evaluated GABA C R-mediated modulation of electrically evoked post synaptic currents using either agonists or antagonists in WT mice. In GABA C ρ1 Null stratum griseum superficiale (SGS) cells, inhibitory postsynaptic currents were shorter in duration and their excitatory postsynaptic currents (EPSCs) were longer, indicating that a slow GABA C R-mediated inhibitory component was reduced in each case. In contrast to retina, GABA C R-mediated currents in the SC were altered but not eliminated in GABA C ρ1 Null mice. In the majority of SC cells in GABA C ρ1 Null mice, GABA C R activation could still be induced to alter EPSC peak amplitudes in putative interneurons and in many projection neurons. These results, compared with previously published data, indicate a fundamental difference between retina and SC in the control of GABA C R expression and subunit composition." @default.
• W2037762444 created "2016-06-24" @default.
• W2037762444 creator A5035702853 @default.
• W2037762444 creator A5066008657 @default.
• W2037762444 creator A5085705294 @default.
• W2037762444 date "2009-06-01" @default.
• W2037762444 modified "2023-10-17" @default.
• W2037762444 title "GABA_C Receptor-Mediated Inhibition Is Altered But Not Eliminated in the Superior Colliculus of GABA_C ρ1 Knockout Mice" @default.
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• W2037762444 doi "https://doi.org/10.1152/jn.91001.2008" @default.
• W2037762444 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3817272" @default.
• W2037762444 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19321639" @default.
• W2037762444 hasPublicationYear "2009" @default.
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