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- W2037763463 abstract "The choroid plexus plays a pivotal role in the production of cerebrospinal fluid (CSF). Messenger RNA (mRNA) transcripts encoding arginine vasopressin (AVP) and the vasopressin 1b receptor (V1bR) are found in various structures of the central nervous system, including the choroid plexus. The present study measured AVP and V1bR mRNA production in response to plasma hyperosmolality. Compared to rats maintained on water, 2% salt-drinking rats had increased levels of AVP and V1bR mRNAs in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus and in the choroid plexus. The increase in V1bR mRNA in the SON and PVN as a result of plasma hyperosmolality may reflect changes in receptor production that, in turn, have a role in AVP autoregulation of hypothalamic magnocellular neurons. The increase of AVP and V1bR mRNAs in the choroid plexus further shows the involvement of AVP in the regulation of brain water content and cerebral edema." @default.
- W2037763463 created "2016-06-24" @default.
- W2037763463 creator A5017658548 @default.
- W2037763463 creator A5067983504 @default.
- W2037763463 date "2001-06-01" @default.
- W2037763463 modified "2023-09-26" @default.
- W2037763463 title "Salt-loading increases vasopressin and vasopressin 1b receptor mRNA in the hypothalamus and choroid plexus" @default.
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- W2037763463 doi "https://doi.org/10.1054/npep.2001.0864" @default.
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