Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037779675> ?p ?o ?g. }
- W2037779675 endingPage "2115" @default.
- W2037779675 startingPage "2115" @default.
- W2037779675 abstract "The DNA replication licensing system ensures that chromosomal DNA is replicated precisely once before cell division occurs. A DNA helicase must be loaded on origin DNA for replication to initiate. Considerable evidence suggests that the MCM complex acts as a replicative helicase in eukaryotes. When the MCM complex is loaded on the chromatin, the replication origin is formally defined as being licensed for replication. Licensing takes place several hours before origins are activated to undergo replication in S-phase. Genetic and biochemical studies show that the licensing process is well conserved in eukaryotes. Cyclin Dependent Kinases (CDKs), the master regulators of the cell cycle, coordinate the initiation of the two key cell cycle events, replication of DNA and its segregation at mitosis. Eukaryotes have developed complex regulatory mechanisms to ensure that origin licensing is coordinated with these events so that genome integrity is preserved during successive cell divisions." @default.
- W2037779675 created "2016-06-24" @default.
- W2037779675 creator A5067922961 @default.
- W2037779675 creator A5085690109 @default.
- W2037779675 date "2004-01-01" @default.
- W2037779675 modified "2023-09-26" @default.
- W2037779675 title "DNA replication licensing" @default.
- W2037779675 cites W1487147936 @default.
- W2037779675 cites W1494346864 @default.
- W2037779675 cites W1506793089 @default.
- W2037779675 cites W1519389973 @default.
- W2037779675 cites W1543201946 @default.
- W2037779675 cites W1547945395 @default.
- W2037779675 cites W1739291674 @default.
- W2037779675 cites W1767329992 @default.
- W2037779675 cites W1875835053 @default.
- W2037779675 cites W1898611373 @default.
- W2037779675 cites W1919702696 @default.
- W2037779675 cites W1964320907 @default.
- W2037779675 cites W1964429281 @default.
- W2037779675 cites W1964439976 @default.
- W2037779675 cites W1966383348 @default.
- W2037779675 cites W1968074226 @default.
- W2037779675 cites W1970515182 @default.
- W2037779675 cites W1973428920 @default.
- W2037779675 cites W1974394081 @default.
- W2037779675 cites W1983356442 @default.
- W2037779675 cites W1984063704 @default.
- W2037779675 cites W1985481802 @default.
- W2037779675 cites W1986773553 @default.
- W2037779675 cites W1989282362 @default.
- W2037779675 cites W1989420337 @default.
- W2037779675 cites W1990520992 @default.
- W2037779675 cites W1992334813 @default.
- W2037779675 cites W1993882349 @default.
- W2037779675 cites W1995024476 @default.
- W2037779675 cites W1995594264 @default.
- W2037779675 cites W1995667706 @default.
- W2037779675 cites W1997408971 @default.
- W2037779675 cites W2002372083 @default.
- W2037779675 cites W2003766273 @default.
- W2037779675 cites W2004536741 @default.
- W2037779675 cites W2005107601 @default.
- W2037779675 cites W2005705565 @default.
- W2037779675 cites W2012931476 @default.
- W2037779675 cites W2017816163 @default.
- W2037779675 cites W2017928245 @default.
- W2037779675 cites W2018370137 @default.
- W2037779675 cites W2018782003 @default.
- W2037779675 cites W2020613572 @default.
- W2037779675 cites W2023536598 @default.
- W2037779675 cites W2026241682 @default.
- W2037779675 cites W2029925140 @default.
- W2037779675 cites W2033661691 @default.
- W2037779675 cites W2033803410 @default.
- W2037779675 cites W2035048264 @default.
- W2037779675 cites W2036008069 @default.
- W2037779675 cites W2037491280 @default.
- W2037779675 cites W2038144609 @default.
- W2037779675 cites W2038692966 @default.
- W2037779675 cites W2039252915 @default.
- W2037779675 cites W2039576441 @default.
- W2037779675 cites W2040778486 @default.
- W2037779675 cites W2041254889 @default.
- W2037779675 cites W2045350461 @default.
- W2037779675 cites W2045631017 @default.
- W2037779675 cites W2048721919 @default.
- W2037779675 cites W2052314828 @default.
- W2037779675 cites W2052566931 @default.
- W2037779675 cites W2052770150 @default.
- W2037779675 cites W2056205588 @default.
- W2037779675 cites W2056590571 @default.
- W2037779675 cites W2057587708 @default.
- W2037779675 cites W2057594508 @default.
- W2037779675 cites W2059594509 @default.
- W2037779675 cites W2060853377 @default.
- W2037779675 cites W2061449183 @default.
- W2037779675 cites W2064234837 @default.
- W2037779675 cites W2065252383 @default.
- W2037779675 cites W2065971145 @default.
- W2037779675 cites W2066677001 @default.
- W2037779675 cites W2069607114 @default.
- W2037779675 cites W2070538760 @default.
- W2037779675 cites W2072382346 @default.
- W2037779675 cites W2072472133 @default.
- W2037779675 cites W2073029277 @default.
- W2037779675 cites W2073166133 @default.
- W2037779675 cites W2074113529 @default.
- W2037779675 cites W2075450948 @default.
- W2037779675 cites W2075641622 @default.
- W2037779675 cites W2079711691 @default.
- W2037779675 cites W2080183231 @default.
- W2037779675 cites W2080284013 @default.
- W2037779675 cites W2080835326 @default.
- W2037779675 cites W2082040415 @default.
- W2037779675 cites W2082507962 @default.
- W2037779675 cites W2082668732 @default.
- W2037779675 cites W2085898164 @default.