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• W2037784512 abstract "Since the times of domestication, cattle have been continually shaped by the influence of humans. Relatively recent history, including breed formation and the still enduring enormous improvement of economically important traits, is expected to have left distinctive footprints of selection within the genome. The purpose of this study was to map genome-wide selection signatures in ten cattle breeds and thus improve the understanding of the genome response to strong artificial selection and support the identification of the underlying genetic variants of favoured phenotypes. We analysed 47,651 single nucleotide polymorphisms (SNP) using Cross Population Extended Haplotype Homozygosity (XP-EHH).We set the significance thresholds using the maximum XP-EHH values of two essentially artificially unselected breeds and found up to 229 selection signatures per breed. Through a confirmation process we verified selection for three distinct phenotypes typical for one breed (polledness in Galloway, double muscling in Blanc-Bleu Belge and red coat colour in Red Holstein cattle). Moreover, we detected six genes strongly associated with known QTL for beef or dairy traits (TG, ABCG2, DGAT1, GH1, GHR and the Casein Cluster) within selection signatures of at least one breed. A literature search for genes lying in outstanding signatures revealed further promising candidate genes. However, in concordance with previous genome-wide studies, we also detected a substantial number of signatures without any yet known gene content.These results show the power of XP-EHH analyses in cattle to discover promising candidate genes and raise the hope of identifying phenotypically important variants in the near future. The finding of plausible functional candidates in some short signatures supports this hope. For instance, MAP2K6 is the only annotated gene of two signatures detected in Galloway and Gelbvieh cattle and is already known to be associated with carcass weight, back fat thickness and marbling score in Korean beef cattle. Based on the confirmation process and literature search we deduce that XP-EHH is able to uncover numerous artificial selection targets in subpopulations of domesticated animals." @default.
• W2037784512 created "2016-06-24" @default.
• W2037784512 creator A5016586826 @default.
• W2037784512 creator A5022820936 @default.
• W2037784512 creator A5046985964 @default.
• W2037784512 creator A5061295210 @default.
• W2037784512 date "2013-12-01" @default.
• W2037784512 modified "2023-10-16" @default.
• W2037784512 title "A genome-wide scan for signatures of differential artificial selection in ten cattle breeds" @default.
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• W2037784512 cites W1966010303 @default.
• W2037784512 cites W1976103073 @default.
• W2037784512 cites W1978500152 @default.
• W2037784512 cites W1981365315 @default.
• W2037784512 cites W1983519055 @default.
• W2037784512 cites W1989923963 @default.
• W2037784512 cites W1999373836 @default.
• W2037784512 cites W2002223230 @default.
• W2037784512 cites W2005395185 @default.
• W2037784512 cites W2005803833 @default.
• W2037784512 cites W2006189274 @default.
• W2037784512 cites W2008644745 @default.
• W2037784512 cites W2020495462 @default.
• W2037784512 cites W2023665348 @default.
• W2037784512 cites W2024434760 @default.
• W2037784512 cites W2025253353 @default.
• W2037784512 cites W2025865441 @default.
• W2037784512 cites W2029009599 @default.
• W2037784512 cites W2030643716 @default.
• W2037784512 cites W2034159975 @default.
• W2037784512 cites W2036069068 @default.
• W2037784512 cites W2037662145 @default.
• W2037784512 cites W2038398109 @default.
• W2037784512 cites W2040680124 @default.
• W2037784512 cites W2042666786 @default.
• W2037784512 cites W2047023422 @default.
• W2037784512 cites W2055543630 @default.
• W2037784512 cites W2058633835 @default.
• W2037784512 cites W2059165575 @default.
• W2037784512 cites W2059542829 @default.
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• W2037784512 cites W2069716488 @default.
• W2037784512 cites W2069913460 @default.
• W2037784512 cites W2080219921 @default.
• W2037784512 cites W2085152040 @default.
• W2037784512 cites W2089833244 @default.
• W2037784512 cites W2093748923 @default.
• W2037784512 cites W2094057369 @default.
• W2037784512 cites W2095626377 @default.
• W2037784512 cites W2098460741 @default.
• W2037784512 cites W2099616263 @default.
• W2037784512 cites W2104146295 @default.
• W2037784512 cites W2104933264 @default.
• W2037784512 cites W2105244939 @default.
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• W2037784512 cites W2109606422 @default.
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• W2037784512 cites W2122633368 @default.
• W2037784512 cites W2130122556 @default.
• W2037784512 cites W2131485985 @default.
• W2037784512 cites W2134958293 @default.
• W2037784512 cites W2136343600 @default.
• W2037784512 cites W2138108018 @default.
• W2037784512 cites W2140276722 @default.
• W2037784512 cites W2150019889 @default.
• W2037784512 cites W2154472853 @default.
• W2037784512 cites W2155315257 @default.
• W2037784512 cites W2156866331 @default.
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• W2037784512 cites W2157149092 @default.
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• W2037784512 doi "https://doi.org/10.1186/1471-2164-14-908" @default.
• W2037784512 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3878089" @default.
• W2037784512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24359457" @default.
• W2037784512 hasPublicationYear "2013" @default.
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