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• W2037789689 abstract "Costunolide is an active sesquiterpene lactone of medicinal herbs with anti-inflammatory and potential anti-cancer activity. Nevertheless, the pharmacological pathways of costunolide have not yet been fully elucidated. In this study we showed that costunolide exerts a dose-dependent antiproliferative activity in the human breast cancer MCF-7 cells. In addition, light microscopy observations indicated that costunolide affected nuclear organization and reorganized microtubule architecture. The antiproliferative and antimicrotubular effects of costunolide were not influenced by paclitaxel, well-known microtubule-stabilizing anticancer agent. The microtubule-interacting activity of costunolide was confirmed by in vitro studies on purified microtubular protein. In fact, costunolide demonstrated polymerizing ability, by inducing the formation of well organized microtubule polymers. Our data suggest an interaction of costunolide with microtubules, which may represent a new intracellular target for this drug." @default.
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• W2037789689 date "2004-01-01" @default.
• W2037789689 modified "2023-09-29" @default.
• W2037789689 title "A sesquiterpene lactone, costunolide, interacts with microtubule protein and inhibits the growth of MCF-7 cells" @default.
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• W2037789689 doi "https://doi.org/10.1016/j.cbi.2003.10.008" @default.
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