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• W2037804593 abstract "Objectives: To evaluate the relationship between T1 after intravenous contrast administration (T1Gd) and Δ relaxation rate (ΔR1) = (1/T1(Gd) − 1/T1o) in the delayed Gadolinium-Enhanced MRI of cartilage (dGEMRIC) evaluation of cartilage repair tissue. Materials and Methods: Thirty single MR examinations from 30 patients after matrix-associated autologous chondrocyte transplantations of the knee joint with different postoperative intervals were examined using an 8-channel knee-coil at 3T. T1 mapping using a 3D GRE sequence with a 35/10° flip angle excitation pulse combination was performed before and after contrast administration (dGEMRIC technique). T1 postcontrast (T1(Gd)) and the ΔR1 (relative index of pre- and postcontrast R1 value) were calculated for repair tissue and the weight-bearing normal appearing control cartilage. For evaluation of the different postoperative intervals, MR exams were subdivided into 3 groups (up to 12 months, 12–24 months, more than 24 months). For statistical analysis Spearman correlation coefficients were calculated. Results: The mean value for T1 postcontrast was 427 ± 159 ms, for ΔR1 1.85 ± 1.0; in reference cartilage 636 ± 181 ms for T1 postcontrast and 0.83 ± 0.5 for ΔR1. The correlation coefficients were highly significant between T1 (Gd) and ΔR1 for repair tissue (0.969) as well as normal reference cartilage (0.928) in total, and for the reparative cartilage in the early, middle postoperative, and late postoperative interval after surgery (R values: −0.986, −0.970, and −0.978, respectively). Using either T1(Gd) or ΔR1, the 2 metrics resulted in similar conclusions regarding the time course of change of repair tissue and control tissue, namely that highly significant (P > 0.01) differences between cartilage repair tissue and reference cartilage were found for all follow-up groups. Additionally, for both metrics highly significant differences (P < 0.01) between early follow up and the 2 later postoperative groups for cartilage repair tissue were found. No statistical differences were found between the 2 later follow-up groups of reparative cartilage either for T1 (Gd) or ΔR1. Conclusion: The high correlation between T1 (Gd) and ΔR1 and the comparable conclusions reached utilizing metric implies that T1 mapping before intravenous administration of MR contrast agent is not necessary for the evaluation of repair tissue. This will help to reduce costs, inconvenience for the patients, simplifies the examination procedure, and makes dGEMRIC more attractive for follow-up of patients after cartilage repair surgeries." @default.
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• W2037804593 date "2009-09-01" @default.
• W2037804593 modified "2023-09-30" @default.
• W2037804593 title "T1(Gd) Gives Comparable Information as Delta T1 Relaxation Rate in dGEMRIC Evaluation of Cartilage Repair Tissue" @default.
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• W2037804593 doi "https://doi.org/10.1097/rli.0b013e3181b4c236" @default.
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