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- W2037804895 abstract "The present study describes a modification of the fast drug-application technique (ticker) which combines two fast-application systems, 'the double-ticker'. With the double-ticker, drugs can be applied to excised patches from either one of the tickers permitting switching among three different solutions in the sub-millisecond range. We made use of this advantageous feature of the double-ticker to study two aspects of the glutamate receptor channel in crayfish muscle. The first concerns revealing the number of glutamate binding sites from measurements of a dose-response relation (2-3 sites). The other relates to the state from which the receptor undergoes desensitization. For the quisqualate-sensitive glutamate receptor desensitization occurs from a closed state. This is in addition to desensitization from an open state." @default.
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- W2037804895 date "1995-10-01" @default.
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- W2037804895 title "The Double-ticker: An Improved Fast Drug-application System Reveals Desensitization of the Glutamate Channel from a Closed State" @default.
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- W2037804895 doi "https://doi.org/10.1111/j.1460-9568.1995.tb00631.x" @default.
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