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- W2037807128 abstract "Blood-levels of trichlorofluoromethane (fluorocarbon-11) ‘Freon-11’, ‘Arcton-11’) were measured in twelve asthmatic patients and three healthy controls. In ten asthmatics who had been chronically overusing pressurised aerosols of adrenergic bronchodilator drugs containing fluorocarbons, fluorocarbon-11 was not detected. After two puffs of a pressurised aerosol, no fluorocarbon-11 was seen in the blood 5 minutes later in these chronic heavy users, nor in two further asthmatics and three controls who had not previously used an aerosol. The peak blood-levels of fluorocarbon-11 in nine subjects (seven asthmatics and two controls) ranged from 0·13 to 2·60 μg, per ml. after two inhalations from one inhaler. The blood half-life of fluorocarbon-11 in six subjects (five asthmatics and one control) ranged from 0·3 to 1·5 minutes. The peak blood-level was not related to lung functions but probably to differences in inhalation technique. It is felt that—at least for fluorocarbon 11—blood-levels in chronic overusers of pressurised aerosols are not likely to be high enough to sensitise the heart to adrenergic compounds." @default.
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- W2037807128 date "2003-10-01" @default.
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- W2037807128 title "P.6.090 Alexithimia anxiety and depression in patients with bronchial asthma" @default.
- W2037807128 doi "https://doi.org/10.1016/s0924-977x(03)92388-1" @default.
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