FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037807428> ?p ?o ?g. }

• W2037807428 endingPage "399" @default.
• W2037807428 startingPage "393" @default.
• W2037807428 abstract "<h3>Introduction/Background</h3> Currently, risk-reducing salpingo-oophorectomy (RRSO) around the age of 40 is recommended to women with a BRCA1/2 pathogenic variant (PV). To prevent premature menopause, risk-reducing salpingectomy (RRS) is considered, because recent data indicate the Fallopian tube instead of the ovary as origin of high grade serous ovarian carcinoma (HGSC). Based on this hypothesis, the TUBA study (NCT02321228) compares quality of life (QoL) between the novel RRS with delayed oophorectomy (RRO) and standard RRSO. <h3>Methodology</h3> Within this national multicenter preference trial, BRCA1/2-PV carriers chose between the novel strategy (RRS upon completion of childbearing and RRO at age 40–45 (BRCA1) or 45–50 (BRCA2)) and the standard strategy (RRSO at age 35–40 (BRCA1) or 40–45 (BRCA2)). The primary outcome is menopause-related QoL, measured by the Greene climacteric scale (GCS). A higher sum of the GCS represents more menopausal complaints. <h3>Results</h3> A total of 577 women were included, 51.5% carried a BRCA1-PV, and 72% chose the novel RRS with delayed RRO. Until now, 394 women underwent RRS and 154 RRSO of which 30% did not start hormone replacement therapy (HRT). Without HRT, the adjusted mean increase from baseline on the GCS was 0.6 points (95% confidence interval (CI) 0.0;1.1) one year after RRS and 7.7 points (95% CI 6.2;9.9) one year after RRSO. Thus, the adjusted mean difference between the treatment groups was 7.2 (95% CI 5.4;9.0, P<0.001). In women with HRT after RRSO, a difference of 3.4 points (95% CI 2.2;4.6, P<0.001) was found compared to RRS. For sexual functioning, women without HRT had an increase of 0.4 points (95% CI -0.3;1.1) one year after RRS and a decrease of 5.7 points (95% CI -8.7;-3.7) one year after RRSO. A decrease of 1.6 points (95% CI -3.2;0.0) was found one year after RRSO with HRT. A decrease represents a worsening of sexual functioning. No differences in cancer worry, decisional conflict or decisional regret were found between groups. No HGSC has occurred during follow-up. <h3>Conclusion</h3> Menopause-related QoL is better after novel RRS when compared to RRSO in women with a BRCA1/2-PV, regardless of HRT use. Moreover, sexual functioning is better at one year after RRS. No cancers have occurred since RRS, but follow-up is too short to draw conclusions on safety. An international follow-up study is currently recruiting to evaluate the oncological safety of RRS with delayed RRO (TUBA-WISP II, NCT04294927). <h3>Disclosures</h3> Nothing to disclose." @default.
• W2037807428 created "2016-06-24" @default.
• W2037807428 creator A5004980235 @default.
• W2037807428 creator A5034622744 @default.
• W2037807428 creator A5048009605 @default.
• W2037807428 creator A5089223522 @default.
• W2037807428 creator A5091447153 @default.
• W2037807428 date "2009-08-03" @default.
• W2037807428 modified "2023-09-28" @default.
• W2037807428 title "Invited Article: Searching for oracles?: Blood biomarkers in acute stroke" @default.
• W2037807428 cites W1771562684 @default.
• W2037807428 cites W1967181084 @default.
• W2037807428 cites W1979893667 @default.
• W2037807428 cites W1990022183 @default.
• W2037807428 cites W1991740017 @default.
• W2037807428 cites W2005018366 @default.
• W2037807428 cites W2012398099 @default.
• W2037807428 cites W2024276472 @default.
• W2037807428 cites W2030516117 @default.
• W2037807428 cites W2038198389 @default.
• W2037807428 cites W2046616634 @default.
• W2037807428 cites W2049373941 @default.
• W2037807428 cites W2052691638 @default.
• W2037807428 cites W2053521005 @default.
• W2037807428 cites W2053999004 @default.
• W2037807428 cites W2056793603 @default.
• W2037807428 cites W2081250348 @default.
• W2037807428 cites W2082315120 @default.
• W2037807428 cites W2084693759 @default.
• W2037807428 cites W2096316234 @default.
• W2037807428 cites W2099457690 @default.
• W2037807428 cites W2100949962 @default.
• W2037807428 cites W2104342714 @default.
• W2037807428 cites W2112628686 @default.
• W2037807428 cites W2116146198 @default.
• W2037807428 cites W2119232786 @default.
• W2037807428 cites W2122866927 @default.
• W2037807428 cites W2124038216 @default.
• W2037807428 cites W2137284770 @default.
• W2037807428 cites W2138768733 @default.
• W2037807428 cites W2139714668 @default.
• W2037807428 cites W2149282020 @default.
• W2037807428 cites W2152140063 @default.
• W2037807428 cites W2163633941 @default.
• W2037807428 cites W2167402790 @default.
• W2037807428 cites W2169185329 @default.
• W2037807428 cites W2169952667 @default.
• W2037807428 cites W2292308933 @default.
• W2037807428 cites W2594075545 @default.
• W2037807428 doi "https://doi.org/10.1212/wnl.0b013e3181b05ef9" @default.
• W2037807428 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2725929" @default.
• W2037807428 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19652144" @default.
• W2037807428 hasPublicationYear "2009" @default.
• W2037807428 type Work @default.
• W2037807428 sameAs 2037807428 @default.
• W2037807428 citedByCount "90" @default.
• W2037807428 countsByYear W20378074282012 @default.
• W2037807428 countsByYear W20378074282013 @default.
• W2037807428 countsByYear W20378074282014 @default.
• W2037807428 countsByYear W20378074282015 @default.
• W2037807428 countsByYear W20378074282016 @default.
• W2037807428 countsByYear W20378074282017 @default.
• W2037807428 countsByYear W20378074282018 @default.
• W2037807428 countsByYear W20378074282019 @default.
• W2037807428 countsByYear W20378074282020 @default.
• W2037807428 countsByYear W20378074282021 @default.
• W2037807428 countsByYear W20378074282022 @default.
• W2037807428 countsByYear W20378074282023 @default.
• W2037807428 crossrefType "journal-article" @default.
• W2037807428 hasAuthorship W2037807428A5004980235 @default.
• W2037807428 hasAuthorship W2037807428A5034622744 @default.
• W2037807428 hasAuthorship W2037807428A5048009605 @default.
• W2037807428 hasAuthorship W2037807428A5089223522 @default.
• W2037807428 hasAuthorship W2037807428A5091447153 @default.
• W2037807428 hasBestOaLocation W20378074282 @default.
• W2037807428 hasConcept C126322002 @default.
• W2037807428 hasConcept C131872663 @default.
• W2037807428 hasConcept C198454886 @default.
• W2037807428 hasConcept C2778562196 @default.
• W2037807428 hasConcept C2779279991 @default.
• W2037807428 hasConcept C2780159708 @default.
• W2037807428 hasConcept C2910557164 @default.
• W2037807428 hasConcept C29456083 @default.
• W2037807428 hasConcept C44249647 @default.
• W2037807428 hasConcept C71924100 @default.
• W2037807428 hasConcept C82789193 @default.
• W2037807428 hasConceptScore W2037807428C126322002 @default.
• W2037807428 hasConceptScore W2037807428C131872663 @default.
• W2037807428 hasConceptScore W2037807428C198454886 @default.
• W2037807428 hasConceptScore W2037807428C2778562196 @default.
• W2037807428 hasConceptScore W2037807428C2779279991 @default.
• W2037807428 hasConceptScore W2037807428C2780159708 @default.
• W2037807428 hasConceptScore W2037807428C2910557164 @default.
• W2037807428 hasConceptScore W2037807428C29456083 @default.
• W2037807428 hasConceptScore W2037807428C44249647 @default.
• W2037807428 hasConceptScore W2037807428C71924100 @default.
• W2037807428 hasConceptScore W2037807428C82789193 @default.
• W2037807428 hasIssue "5" @default.

• next