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- W2037807737 abstract "The by-product from a synthetic heroin is 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a chemical contaminant found to produce neurotoxicity similar to Parkinsonism in susceptible animals. MPTP and its oxidative metabolites were tested in the Salmonella mutagenicity test. Strains of Salmonella typhimurium that carry a nonsense mutation at the site of reversion detect a variety of naturally occurring and direct-acting mutagens. TA 100 is reverted by MPDP+ (1-methyl-4-phenyl-2,3-dihydropyridinium species). This strain is more sensitive to MPDP+ mutagenesis than any other available strain of Salmonella and MPDP+ is considerably more mutagenic than MPTP and other oxidative metabolites including MPTP N-oxide or MPP+ (1-methyl-4-phenylpyridinium ion). Mutagenicity studies of metabolic incubates of MPTP with monoamine oxidase (MAO) suggest the involvement of metabolic bioactivation in the mutagenicity of MPTP. Since MPDP+ is generated from MPTP by MAO and since iminium ions are generated during cellular metabolism, they may make a contribution to the risk of human cancer." @default.
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- W2037807737 date "1987-02-01" @default.
- W2037807737 modified "2023-09-23" @default.
- W2037807737 title "Mutagenicity of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) and its metabolites" @default.
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- W2037807737 doi "https://doi.org/10.1016/0300-483x(87)90007-2" @default.
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