Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037808521> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2037808521 endingPage "20" @default.
- W2037808521 startingPage "13" @default.
- W2037808521 abstract "To identify the pathogenic factors responsible for glucose intolerance of aging, we measured a variety of metabolic parameters, including insulin sensitivity and islet cell function, in 10 young (18-36 yr old) and 10 older (57-82 yr old) men of normal body weight. Subject groups had equivalent fasting plasma glucose and fat cell size values. Frequently sampled iv glucose tolerance tests were performed, and the data were analyzed by computer using the minimal model approach. This technique yields the following measures: SI, the insulin sensitivity index; phi 1 and phi 2, indices of first and second phase beta-cell responsiveness to glucose; n, fractional insulin clearance, and SG, a measure of dynamic glucose disappearance dependent on glucose per se. We also evaluated beta-cell responsiveness independently by measuring the plasma insulin response to arginine injections at three levels of glycemia and calculated potentiation slope from the relationship between the acute insulin response to arginine and the prestimulus glucose level. The older men were glucose intolerant (glucose disappearance rate, 1.32% min-1) compared to the younger men (glucose disappearance rate, 2.21% min-1; P less than 0.01). This intolerance was the result of both a beta-cell defect and insulin resistance. The potentiation slope (r = -0.67; P less than 0.02) and phi 2 (r = -0.47; P less than 0.05) both decreased with age. In addition, SI in the older group was diminished 63% (2.4 vs. 6.5; 10(-4) min-1/microU/ml; P less than 0.001) and was unrelated to differences in body fat. No differences were found in either n or SG. These studies suggest that the diminished glucose tolerance of aging in normal weight men has multifactorial causality. Both beta-cell dysfunction and insulin resistance are important. In contrast, we found little evidence for changes in insulin clearance or insulin-independent glucose disappearance contributing to age-related glucose intolerance." @default.
- W2037808521 created "2016-06-24" @default.
- W2037808521 creator A5000277537 @default.
- W2037808521 creator A5030791389 @default.
- W2037808521 creator A5054707430 @default.
- W2037808521 creator A5072056585 @default.
- W2037808521 date "1985-01-01" @default.
- W2037808521 modified "2023-10-12" @default.
- W2037808521 title "Pathogenesis of Age-Related Glucose Intolerance in Man: Insulin Resistance and Decreased β-Cell Function*" @default.
- W2037808521 doi "https://doi.org/10.1210/jcem-60-1-13" @default.
- W2037808521 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3880560" @default.
- W2037808521 hasPublicationYear "1985" @default.
- W2037808521 type Work @default.
- W2037808521 sameAs 2037808521 @default.
- W2037808521 citedByCount "336" @default.
- W2037808521 countsByYear W20378085212012 @default.
- W2037808521 countsByYear W20378085212013 @default.
- W2037808521 countsByYear W20378085212014 @default.
- W2037808521 countsByYear W20378085212015 @default.
- W2037808521 countsByYear W20378085212016 @default.
- W2037808521 countsByYear W20378085212017 @default.
- W2037808521 countsByYear W20378085212018 @default.
- W2037808521 countsByYear W20378085212019 @default.
- W2037808521 countsByYear W20378085212020 @default.
- W2037808521 countsByYear W20378085212021 @default.
- W2037808521 countsByYear W20378085212022 @default.
- W2037808521 countsByYear W20378085212023 @default.
- W2037808521 crossrefType "journal-article" @default.
- W2037808521 hasAuthorship W2037808521A5000277537 @default.
- W2037808521 hasAuthorship W2037808521A5030791389 @default.
- W2037808521 hasAuthorship W2037808521A5054707430 @default.
- W2037808521 hasAuthorship W2037808521A5072056585 @default.
- W2037808521 hasBestOaLocation W20378085211 @default.
- W2037808521 hasConcept C126322002 @default.
- W2037808521 hasConcept C134018914 @default.
- W2037808521 hasConcept C165220095 @default.
- W2037808521 hasConcept C2776828364 @default.
- W2037808521 hasConcept C2777391703 @default.
- W2037808521 hasConcept C2777468819 @default.
- W2037808521 hasConcept C2779306644 @default.
- W2037808521 hasConcept C2780352109 @default.
- W2037808521 hasConcept C2780609358 @default.
- W2037808521 hasConcept C2780833929 @default.
- W2037808521 hasConcept C2780942790 @default.
- W2037808521 hasConcept C3017594758 @default.
- W2037808521 hasConcept C3020574416 @default.
- W2037808521 hasConcept C515207424 @default.
- W2037808521 hasConcept C55493867 @default.
- W2037808521 hasConcept C555293320 @default.
- W2037808521 hasConcept C71924100 @default.
- W2037808521 hasConcept C86803240 @default.
- W2037808521 hasConceptScore W2037808521C126322002 @default.
- W2037808521 hasConceptScore W2037808521C134018914 @default.
- W2037808521 hasConceptScore W2037808521C165220095 @default.
- W2037808521 hasConceptScore W2037808521C2776828364 @default.
- W2037808521 hasConceptScore W2037808521C2777391703 @default.
- W2037808521 hasConceptScore W2037808521C2777468819 @default.
- W2037808521 hasConceptScore W2037808521C2779306644 @default.
- W2037808521 hasConceptScore W2037808521C2780352109 @default.
- W2037808521 hasConceptScore W2037808521C2780609358 @default.
- W2037808521 hasConceptScore W2037808521C2780833929 @default.
- W2037808521 hasConceptScore W2037808521C2780942790 @default.
- W2037808521 hasConceptScore W2037808521C3017594758 @default.
- W2037808521 hasConceptScore W2037808521C3020574416 @default.
- W2037808521 hasConceptScore W2037808521C515207424 @default.
- W2037808521 hasConceptScore W2037808521C55493867 @default.
- W2037808521 hasConceptScore W2037808521C555293320 @default.
- W2037808521 hasConceptScore W2037808521C71924100 @default.
- W2037808521 hasConceptScore W2037808521C86803240 @default.
- W2037808521 hasIssue "1" @default.
- W2037808521 hasLocation W20378085211 @default.
- W2037808521 hasLocation W20378085212 @default.
- W2037808521 hasOpenAccess W2037808521 @default.
- W2037808521 hasPrimaryLocation W20378085211 @default.
- W2037808521 hasRelatedWork W2026316039 @default.
- W2037808521 hasRelatedWork W2037808521 @default.
- W2037808521 hasRelatedWork W2042617115 @default.
- W2037808521 hasRelatedWork W2050758338 @default.
- W2037808521 hasRelatedWork W2084623371 @default.
- W2037808521 hasRelatedWork W2089518257 @default.
- W2037808521 hasRelatedWork W2094672900 @default.
- W2037808521 hasRelatedWork W2368528961 @default.
- W2037808521 hasRelatedWork W2402098708 @default.
- W2037808521 hasRelatedWork W2884204026 @default.
- W2037808521 hasVolume "60" @default.
- W2037808521 isParatext "false" @default.
- W2037808521 isRetracted "false" @default.
- W2037808521 magId "2037808521" @default.
- W2037808521 workType "article" @default.