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- W2037817730 endingPage "368" @default.
- W2037817730 startingPage "352" @default.
- W2037817730 abstract "Metal ions, especially redox active copper, are thought to play critical roles in neurodegenerative disorders. As a matter of fact, metal binding may result into severe conformational changes of proteins involved in neurodegeneration. The present review describes the interactions of metal ions with model peptides mimicking metal binding sites of such proteins, including the prion protein, the β-amyloid and the α-synuclein that have been related to the pathological onset of spongiform encephalopathies, Alzheimer's disease and Parkinson's disease, respectively. Using short protein fragments provides successful tools for characterizing the metal ion interaction with protein domains devoid of any defined secondary structure, and allows one to gain structural information on the metal ion binding properties of the corresponding proteins. Moreover, such an approach based on simplified models yields a multidimensional knowledge that would be never accessible for the natural systems, thus providing a significant and powerful tool for biochemical studies." @default.
- W2037817730 created "2016-06-24" @default.
- W2037817730 creator A5005543896 @default.
- W2037817730 creator A5009218318 @default.
- W2037817730 creator A5027103801 @default.
- W2037817730 creator A5073109842 @default.
- W2037817730 date "2012-01-01" @default.
- W2037817730 modified "2023-10-15" @default.
- W2037817730 title "Structural characterization of Cu2+, Ni2+ and Zn2+ binding sites of model peptides associated with neurodegenerative diseases" @default.
- W2037817730 cites W149247114 @default.
- W2037817730 cites W1510383592 @default.
- W2037817730 cites W1520164098 @default.
- W2037817730 cites W1527671059 @default.
- W2037817730 cites W1538748480 @default.
- W2037817730 cites W1555658886 @default.
- W2037817730 cites W1632936309 @default.
- W2037817730 cites W1707143272 @default.
- W2037817730 cites W1864253247 @default.
- W2037817730 cites W1961758357 @default.
- W2037817730 cites W1963698191 @default.
- W2037817730 cites W1963712466 @default.
- W2037817730 cites W1964249554 @default.
- W2037817730 cites W1964937957 @default.
- W2037817730 cites W1965556778 @default.
- W2037817730 cites W1968830969 @default.
- W2037817730 cites W1970716063 @default.
- W2037817730 cites W1971348798 @default.
- W2037817730 cites W1972409470 @default.
- W2037817730 cites W1973709984 @default.
- W2037817730 cites W1974643980 @default.
- W2037817730 cites W1976951513 @default.
- W2037817730 cites W1977802866 @default.
- W2037817730 cites W1978424761 @default.
- W2037817730 cites W1979833383 @default.
- W2037817730 cites W1980709163 @default.
- W2037817730 cites W1981439327 @default.
- W2037817730 cites W1981471614 @default.
- W2037817730 cites W1982635793 @default.
- W2037817730 cites W1982676722 @default.
- W2037817730 cites W1984676214 @default.
- W2037817730 cites W1985110467 @default.
- W2037817730 cites W1986464882 @default.
- W2037817730 cites W1986803075 @default.
- W2037817730 cites W1987566729 @default.
- W2037817730 cites W1989403800 @default.
- W2037817730 cites W1990473626 @default.
- W2037817730 cites W1991039509 @default.
- W2037817730 cites W1993943470 @default.
- W2037817730 cites W1994939101 @default.
- W2037817730 cites W1995999409 @default.
- W2037817730 cites W1996941571 @default.
- W2037817730 cites W1996947727 @default.
- W2037817730 cites W1998115145 @default.
- W2037817730 cites W1999967750 @default.
- W2037817730 cites W2000734024 @default.
- W2037817730 cites W2001148956 @default.
- W2037817730 cites W2002768329 @default.
- W2037817730 cites W2004158667 @default.
- W2037817730 cites W2004994031 @default.
- W2037817730 cites W2005379695 @default.
- W2037817730 cites W2005693512 @default.
- W2037817730 cites W2005727122 @default.
- W2037817730 cites W2006422372 @default.
- W2037817730 cites W2007259620 @default.
- W2037817730 cites W2007710639 @default.
- W2037817730 cites W2008345691 @default.
- W2037817730 cites W2008430794 @default.
- W2037817730 cites W2008649582 @default.
- W2037817730 cites W2009092503 @default.
- W2037817730 cites W2009127422 @default.
- W2037817730 cites W2009833553 @default.
- W2037817730 cites W2010149959 @default.
- W2037817730 cites W2010943034 @default.
- W2037817730 cites W2012120090 @default.
- W2037817730 cites W2012128918 @default.
- W2037817730 cites W2013290736 @default.
- W2037817730 cites W2013615657 @default.
- W2037817730 cites W2015566874 @default.
- W2037817730 cites W2015637693 @default.
- W2037817730 cites W2015675204 @default.
- W2037817730 cites W2016247254 @default.
- W2037817730 cites W2017550829 @default.
- W2037817730 cites W2018333394 @default.
- W2037817730 cites W2019511555 @default.
- W2037817730 cites W2019566871 @default.
- W2037817730 cites W2020399348 @default.
- W2037817730 cites W2020787157 @default.
- W2037817730 cites W2022058058 @default.
- W2037817730 cites W2022392367 @default.
- W2037817730 cites W2022830173 @default.
- W2037817730 cites W2023918463 @default.
- W2037817730 cites W2024445488 @default.
- W2037817730 cites W2024710814 @default.
- W2037817730 cites W2025200427 @default.
- W2037817730 cites W2025615265 @default.
- W2037817730 cites W2026606393 @default.
- W2037817730 cites W2026613451 @default.
- W2037817730 cites W2026676471 @default.