Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037819131> ?p ?o ?g. }
- W2037819131 endingPage "85" @default.
- W2037819131 startingPage "76" @default.
- W2037819131 abstract "The Nogo-66 receptor NgR has been implicated in the mediation of inhibitory effects of central nervous system (CNS) myelin on axon growth in the adult mammalian CNS. NgR binds to several myelin-associated ligands (Nogo-66, myelin associated glycoprotein, and oligodendrocyte-myelin glycoprotein), which, among other inhibitory proteins, impair axonal regeneration in the CNS of adult mammals. In contrast to mammals, severed axons readily regenerate in the fish CNS. Nevertheless, fish axons are repelled by mammalian oligodendrocytes in vitro. Therefore, the identification of fish NgR homologs is a crucial step towards understanding NgR functions in vertebrate systems competent of CNS regeneration. Here, we report the discovery of four zebrafish (Danio rerio) and five fugu (Takifugu rubripes) NgR homologs. Synteny between fish and human, comparable intron-exon structures, and phylogenetic analyses provide convincing evidence that the true fish orthologs were identified. The topology of the phylogenetic trees shows that the extra fish genes were produced by duplication events that occurred in ray-finned fishes before the divergence of the zebrafish and pufferfish lineages. Expression of zebrafish NgR homologs was detected relatively early in development and prominently in the adult brain, suggesting functions in axon growth, guidance, or plasticity." @default.
- W2037819131 created "2016-06-24" @default.
- W2037819131 creator A5000518705 @default.
- W2037819131 creator A5013732349 @default.
- W2037819131 creator A5016094203 @default.
- W2037819131 creator A5052991987 @default.
- W2037819131 creator A5057817479 @default.
- W2037819131 creator A5071698358 @default.
- W2037819131 date "2004-01-01" @default.
- W2037819131 modified "2023-09-24" @default.
- W2037819131 title "Identification of Nogo-66 Receptor (NgR) and Homologous Genes in Fish" @default.
- W2037819131 cites W1491610362 @default.
- W2037819131 cites W1500809101 @default.
- W2037819131 cites W1501639391 @default.
- W2037819131 cites W1581606382 @default.
- W2037819131 cites W1582674063 @default.
- W2037819131 cites W1601004977 @default.
- W2037819131 cites W1952053031 @default.
- W2037819131 cites W1967450020 @default.
- W2037819131 cites W1971304382 @default.
- W2037819131 cites W1991024347 @default.
- W2037819131 cites W1991539783 @default.
- W2037819131 cites W1999145879 @default.
- W2037819131 cites W2009596137 @default.
- W2037819131 cites W2015633789 @default.
- W2037819131 cites W2032304318 @default.
- W2037819131 cites W2034844685 @default.
- W2037819131 cites W2034911186 @default.
- W2037819131 cites W2051112456 @default.
- W2037819131 cites W2056068926 @default.
- W2037819131 cites W2070118546 @default.
- W2037819131 cites W2097403532 @default.
- W2037819131 cites W2103497223 @default.
- W2037819131 cites W2106882534 @default.
- W2037819131 cites W2117097628 @default.
- W2037819131 cites W2120960764 @default.
- W2037819131 cites W2133104753 @default.
- W2037819131 cites W2143210482 @default.
- W2037819131 cites W2158714788 @default.
- W2037819131 cites W2161444534 @default.
- W2037819131 cites W2164325979 @default.
- W2037819131 cites W2171091522 @default.
- W2037819131 cites W2171946109 @default.
- W2037819131 cites W4254275792 @default.
- W2037819131 doi "https://doi.org/10.1093/molbev/msg241" @default.
- W2037819131 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12949137" @default.
- W2037819131 hasPublicationYear "2004" @default.
- W2037819131 type Work @default.
- W2037819131 sameAs 2037819131 @default.
- W2037819131 citedByCount "34" @default.
- W2037819131 countsByYear W20378191312013 @default.
- W2037819131 countsByYear W20378191312014 @default.
- W2037819131 countsByYear W20378191312015 @default.
- W2037819131 countsByYear W20378191312016 @default.
- W2037819131 countsByYear W20378191312017 @default.
- W2037819131 countsByYear W20378191312018 @default.
- W2037819131 countsByYear W20378191312020 @default.
- W2037819131 crossrefType "journal-article" @default.
- W2037819131 hasAuthorship W2037819131A5000518705 @default.
- W2037819131 hasAuthorship W2037819131A5013732349 @default.
- W2037819131 hasAuthorship W2037819131A5016094203 @default.
- W2037819131 hasAuthorship W2037819131A5052991987 @default.
- W2037819131 hasAuthorship W2037819131A5057817479 @default.
- W2037819131 hasAuthorship W2037819131A5071698358 @default.
- W2037819131 hasBestOaLocation W20378191311 @default.
- W2037819131 hasConcept C104317684 @default.
- W2037819131 hasConcept C141231307 @default.
- W2037819131 hasConcept C169760540 @default.
- W2037819131 hasConcept C2776878037 @default.
- W2037819131 hasConcept C2777469381 @default.
- W2037819131 hasConcept C2778609137 @default.
- W2037819131 hasConcept C2778961482 @default.
- W2037819131 hasConcept C2780384893 @default.
- W2037819131 hasConcept C529278444 @default.
- W2037819131 hasConcept C53702515 @default.
- W2037819131 hasConcept C54355233 @default.
- W2037819131 hasConcept C8162170 @default.
- W2037819131 hasConcept C86803240 @default.
- W2037819131 hasConcept C95444343 @default.
- W2037819131 hasConceptScore W2037819131C104317684 @default.
- W2037819131 hasConceptScore W2037819131C141231307 @default.
- W2037819131 hasConceptScore W2037819131C169760540 @default.
- W2037819131 hasConceptScore W2037819131C2776878037 @default.
- W2037819131 hasConceptScore W2037819131C2777469381 @default.
- W2037819131 hasConceptScore W2037819131C2778609137 @default.
- W2037819131 hasConceptScore W2037819131C2778961482 @default.
- W2037819131 hasConceptScore W2037819131C2780384893 @default.
- W2037819131 hasConceptScore W2037819131C529278444 @default.
- W2037819131 hasConceptScore W2037819131C53702515 @default.
- W2037819131 hasConceptScore W2037819131C54355233 @default.
- W2037819131 hasConceptScore W2037819131C8162170 @default.
- W2037819131 hasConceptScore W2037819131C86803240 @default.
- W2037819131 hasConceptScore W2037819131C95444343 @default.
- W2037819131 hasIssue "1" @default.
- W2037819131 hasLocation W20378191311 @default.
- W2037819131 hasLocation W20378191312 @default.
- W2037819131 hasLocation W20378191313 @default.
- W2037819131 hasOpenAccess W2037819131 @default.