FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037828207> ?p ?o ?g. }

• W2037828207 endingPage "155" @default.
• W2037828207 startingPage "148" @default.
• W2037828207 abstract "Huntington's disease is caused by a single mutation resulting in an expanded polyglutamine sequence which causes the production of a mutant variant of the protein huntingtin, which is ultimately responsible for the motor, cognitive and emotional symptoms and early death of the individual. Several mouse models have been created that seek to recapitulate the features of the disease. The present study sought to characterise the Hdh(Q92) mouse line longitudinally, to determine the nature, extent and age of onset of any behavioural deficits. On each of the tests used the Hdh(Q92/Q92) mice demonstrated poorer performance than their wildtype littermates, and these performance deficits were age dependent. Of the tests applied acoustic startle and prepulse inhibition proved to be the most sensitive with differences between the mouse groups appearing ∼4 months of age, an age where grip strength differences were also found. Male Hdh(Q92/Q92) mice started losing weight relative their wildtype littermates from 10 months of age, and water maze performance began to deteriorate from 14 months. There were slight differences in rotarod ability with advancing age, with the Hdh(Q92/Q92) demonstrating greater variability in performance than their wildtype littermates. Analysis of body weight and the initial stage of the water maze procedure produced clear between group differences, whereas the grip strength, rotarod and acoustic startle tests demonstrated significance only when age was a factor in the analyses, suggesting that changes in the pattern of performance over time were responsible for the differences, rather than overall group effects per se. The results highlight the necessity for the longitudinal assessment of mouse lines to detect subtle behavioural differences experimental groups." @default.
• W2037828207 created "2016-06-24" @default.
• W2037828207 creator A5026981679 @default.
• W2037828207 creator A5039606775 @default.
• W2037828207 creator A5065920088 @default.
• W2037828207 creator A5071636673 @default.
• W2037828207 date "2012-06-01" @default.
• W2037828207 modified "2023-09-23" @default.
• W2037828207 title "Longitudinal analysis of the behavioural phenotype in HdhQ92 Huntington's disease knock-in mice" @default.
• W2037828207 cites W1567614403 @default.
• W2037828207 cites W1651597776 @default.
• W2037828207 cites W1920278102 @default.
• W2037828207 cites W1964666126 @default.
• W2037828207 cites W1977619632 @default.
• W2037828207 cites W1983355263 @default.
• W2037828207 cites W1985474993 @default.
• W2037828207 cites W1985901002 @default.
• W2037828207 cites W1987519006 @default.
• W2037828207 cites W1989921507 @default.
• W2037828207 cites W1990543487 @default.
• W2037828207 cites W2002116168 @default.
• W2037828207 cites W2010521418 @default.
• W2037828207 cites W2019634326 @default.
• W2037828207 cites W2030246136 @default.
• W2037828207 cites W2031584365 @default.
• W2037828207 cites W2033030349 @default.
• W2037828207 cites W2041171891 @default.
• W2037828207 cites W2041479028 @default.
• W2037828207 cites W2062682951 @default.
• W2037828207 cites W2075565242 @default.
• W2037828207 cites W2082056883 @default.
• W2037828207 cites W2090041950 @default.
• W2037828207 cites W2094450187 @default.
• W2037828207 cites W2095294770 @default.
• W2037828207 cites W2097087260 @default.
• W2037828207 cites W2100876024 @default.
• W2037828207 cites W2103337402 @default.
• W2037828207 cites W2103716597 @default.
• W2037828207 cites W2105046145 @default.
• W2037828207 cites W2107514471 @default.
• W2037828207 cites W2107522917 @default.
• W2037828207 cites W2108003276 @default.
• W2037828207 cites W2112793851 @default.
• W2037828207 cites W2121642311 @default.
• W2037828207 cites W2123762857 @default.
• W2037828207 cites W2136468386 @default.
• W2037828207 cites W2142125979 @default.
• W2037828207 cites W2159074414 @default.
• W2037828207 cites W2165944043 @default.
• W2037828207 cites W2168133967 @default.
• W2037828207 cites W2168583567 @default.
• W2037828207 cites W2169473035 @default.
• W2037828207 cites W2170256902 @default.
• W2037828207 cites W2680511221 @default.
• W2037828207 cites W2749190633 @default.
• W2037828207 cites W4254474377 @default.
• W2037828207 doi "https://doi.org/10.1016/j.brainresbull.2010.05.003" @default.
• W2037828207 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20457230" @default.
• W2037828207 hasPublicationYear "2012" @default.
• W2037828207 type Work @default.
• W2037828207 sameAs 2037828207 @default.
• W2037828207 citedByCount "37" @default.
• W2037828207 countsByYear W20378282072012 @default.
• W2037828207 countsByYear W20378282072013 @default.
• W2037828207 countsByYear W20378282072014 @default.
• W2037828207 countsByYear W20378282072015 @default.
• W2037828207 countsByYear W20378282072016 @default.
• W2037828207 countsByYear W20378282072017 @default.
• W2037828207 countsByYear W20378282072018 @default.
• W2037828207 countsByYear W20378282072019 @default.
• W2037828207 countsByYear W20378282072022 @default.
• W2037828207 countsByYear W20378282072023 @default.
• W2037828207 crossrefType "journal-article" @default.
• W2037828207 hasAuthorship W2037828207A5026981679 @default.
• W2037828207 hasAuthorship W2037828207A5039606775 @default.
• W2037828207 hasAuthorship W2037828207A5065920088 @default.
• W2037828207 hasAuthorship W2037828207A5071636673 @default.
• W2037828207 hasConcept C104317684 @default.
• W2037828207 hasConcept C118552586 @default.
• W2037828207 hasConcept C126322002 @default.
• W2037828207 hasConcept C134018914 @default.
• W2037828207 hasConcept C141421786 @default.
• W2037828207 hasConcept C143065580 @default.
• W2037828207 hasConcept C15744967 @default.
• W2037828207 hasConcept C169760540 @default.
• W2037828207 hasConcept C169900460 @default.
• W2037828207 hasConcept C207583985 @default.
• W2037828207 hasConcept C2776412080 @default.
• W2037828207 hasConcept C2777433710 @default.
• W2037828207 hasConcept C2777845764 @default.
• W2037828207 hasConcept C2777981454 @default.
• W2037828207 hasConcept C2779134260 @default.
• W2037828207 hasConcept C2780647506 @default.
• W2037828207 hasConcept C2781427258 @default.
• W2037828207 hasConcept C2909172351 @default.
• W2037828207 hasConcept C2985495968 @default.
• W2037828207 hasConcept C42407357 @default.
• W2037828207 hasConcept C44752575 @default.

• next