FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037837746> ?p ?o ?g. }

• W2037837746 endingPage "837" @default.
• W2037837746 startingPage "831" @default.
• W2037837746 abstract "The major part of hepatocellular iron is derived from uptake of transferrin-bound iron by means of nonspecific fluid-phase endocytosis and specific, saturable binding on high-affinity transferrin receptors. We investigated the expression of transferrin receptors on hepatocytes in liver biopsies of 22 cases of hemochromatosis (21 primary hemochromatosis and 1 secondary hemochromatosis), using immunohistochemical demonstration of the human transferrin receptor with the specific monoclonal antibody OKT9. Fifty liver biopsies (normal and pathological) without demonstrable iron storage (Perls' stain negative) served as controls. In the controls, membranous and/or cytoplasmic transferrin receptor expression was always present on hepatocytes, albeit in variable numbers and patterns without obvious relation to the underlying liver disease. In 19 of 22 hemochromatosis cases with severe iron overload, OKT9 immunoreactivity on hepatocytes was completely absent. Three hemochromatosis cases showed few hepatocytes positive for OKT9. One showed mild iron overload, while the second, a successfully treated case, was free of iron. The remaining hemochromatosis case was a known alcoholic with severe iron overload. Since OKT9 binding to the transferrin receptor is not blocked by previous binding of transferrin, the findings show that in advanced hemochromatosis hepatocytes do not express transferrin receptors. This finding is in keeping with the inverse relation between transferrin receptor expression and exogenous iron supply in various cell cultures. These results indicate that in hemochromatosis, apparently as a result of progressive iron overload, transferrin receptor expression on hepatocytes disappears. This leaves the hepatocytes with a nonsaturable mechanism for uptake of transferrin-bound iron (fluid-phase pinocytosis) and with uptake of potentially more toxic forms of nontransferrin-bound iron, which may represent up to 30% of serum iron in fully established hemochromatosis." @default.
• W2037837746 created "2016-06-24" @default.
• W2037837746 creator A5018140442 @default.
• W2037837746 creator A5076297902 @default.
• W2037837746 creator A5086102127 @default.
• W2037837746 creator A5086784384 @default.
• W2037837746 date "1987-09-01" @default.
• W2037837746 modified "2023-10-16" @default.
• W2037837746 title "Lack of hepatic transferrin receptor expression in hemochromatosis" @default.
• W2037837746 cites W1502690419 @default.
• W2037837746 cites W1515388283 @default.
• W2037837746 cites W1549632498 @default.
• W2037837746 cites W1561905104 @default.
• W2037837746 cites W1591975847 @default.
• W2037837746 cites W1929077606 @default.
• W2037837746 cites W1962690668 @default.
• W2037837746 cites W1979601721 @default.
• W2037837746 cites W1988880699 @default.
• W2037837746 cites W2002434192 @default.
• W2037837746 cites W2003106565 @default.
• W2037837746 cites W2022483083 @default.
• W2037837746 cites W2025457574 @default.
• W2037837746 cites W2026457056 @default.
• W2037837746 cites W2033122648 @default.
• W2037837746 cites W2035152288 @default.
• W2037837746 cites W2039431883 @default.
• W2037837746 cites W2056149198 @default.
• W2037837746 cites W2070335414 @default.
• W2037837746 cites W2072705032 @default.
• W2037837746 cites W2073640891 @default.
• W2037837746 cites W2091630752 @default.
• W2037837746 cites W2091806624 @default.
• W2037837746 cites W2092177329 @default.
• W2037837746 cites W2094105345 @default.
• W2037837746 cites W2126320114 @default.
• W2037837746 cites W2134950162 @default.
• W2037837746 cites W2152183134 @default.
• W2037837746 cites W2152618121 @default.
• W2037837746 cites W2166848214 @default.
• W2037837746 cites W2174573717 @default.
• W2037837746 cites W2233306577 @default.
• W2037837746 cites W2343187190 @default.
• W2037837746 cites W2427510662 @default.
• W2037837746 cites W2442341764 @default.
• W2037837746 cites W2996995245 @default.
• W2037837746 cites W4232727289 @default.
• W2037837746 doi "https://doi.org/10.1002/hep.1840070507" @default.
• W2037837746 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3308665" @default.
• W2037837746 hasPublicationYear "1987" @default.
• W2037837746 type Work @default.
• W2037837746 sameAs 2037837746 @default.
• W2037837746 citedByCount "85" @default.
• W2037837746 countsByYear W20378377462013 @default.
• W2037837746 countsByYear W20378377462014 @default.
• W2037837746 countsByYear W20378377462017 @default.
• W2037837746 crossrefType "journal-article" @default.
• W2037837746 hasAuthorship W2037837746A5018140442 @default.
• W2037837746 hasAuthorship W2037837746A5076297902 @default.
• W2037837746 hasAuthorship W2037837746A5086102127 @default.
• W2037837746 hasAuthorship W2037837746A5086784384 @default.
• W2037837746 hasBestOaLocation W20378377461 @default.
• W2037837746 hasConcept C126322002 @default.
• W2037837746 hasConcept C134018914 @default.
• W2037837746 hasConcept C170493617 @default.
• W2037837746 hasConcept C185592680 @default.
• W2037837746 hasConcept C22814914 @default.
• W2037837746 hasConcept C2776590208 @default.
• W2037837746 hasConcept C3018783601 @default.
• W2037837746 hasConcept C32264632 @default.
• W2037837746 hasConcept C55493867 @default.
• W2037837746 hasConcept C71924100 @default.
• W2037837746 hasConcept C86803240 @default.
• W2037837746 hasConceptScore W2037837746C126322002 @default.
• W2037837746 hasConceptScore W2037837746C134018914 @default.
• W2037837746 hasConceptScore W2037837746C170493617 @default.
• W2037837746 hasConceptScore W2037837746C185592680 @default.
• W2037837746 hasConceptScore W2037837746C22814914 @default.
• W2037837746 hasConceptScore W2037837746C2776590208 @default.
• W2037837746 hasConceptScore W2037837746C3018783601 @default.
• W2037837746 hasConceptScore W2037837746C32264632 @default.
• W2037837746 hasConceptScore W2037837746C55493867 @default.
• W2037837746 hasConceptScore W2037837746C71924100 @default.
• W2037837746 hasConceptScore W2037837746C86803240 @default.
• W2037837746 hasIssue "5" @default.
• W2037837746 hasLocation W20378377461 @default.
• W2037837746 hasLocation W20378377462 @default.
• W2037837746 hasOpenAccess W2037837746 @default.
• W2037837746 hasPrimaryLocation W20378377461 @default.
• W2037837746 hasRelatedWork W1985279299 @default.
• W2037837746 hasRelatedWork W1991250386 @default.
• W2037837746 hasRelatedWork W1995544089 @default.
• W2037837746 hasRelatedWork W2001564713 @default.
• W2037837746 hasRelatedWork W2055398309 @default.
• W2037837746 hasRelatedWork W2066822786 @default.
• W2037837746 hasRelatedWork W2126659607 @default.
• W2037837746 hasRelatedWork W2183684771 @default.
• W2037837746 hasRelatedWork W2404944273 @default.
• W2037837746 hasRelatedWork W2595188748 @default.

• next