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• W2037839938 abstract "Many therapeutic carrier materials were exploited for human gene therapy from viral to polymeric vectors. This research describes the evaluation of two biodegradable ester-bonded polymers synthesized by double-monomer polycondensation for a non-viral cationic polymer-based gene delivery system. The backbone was constructed to include inner tertiary amines and outer primary amines. Self-assembly with DNA resulted in the production of regularly nano-sized spherical polyplexes with good transfection efficiency, especially in the presence of serum. The polymers showed a relatively slow degradability for an amine-containing ester polymer, as they maintained DNA/polymer complex for 7 days in physiological buffer conditions. Finally, the low toxicity and slow degradation concluded these polymers reliable for long-term therapeutic applications." @default.
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• W2037839938 date "2007-02-01" @default.
• W2037839938 modified "2023-10-16" @default.
• W2037839938 title "Synthesis and characterization of poly (amino ester) for slow biodegradable gene delivery vector" @default.
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• W2037839938 doi "https://doi.org/10.1016/j.bmc.2006.12.004" @default.
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