FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037842354> ?p ?o ?g. }

• W2037842354 endingPage "1777" @default.
• W2037842354 startingPage "1772" @default.
• W2037842354 abstract "Outer membrane proteins (OMPs) of Gram-negative bacteria are synthesized in the cytosol and must cross the periplasm before insertion into the outer membrane. The 17-kDa protein (Skp) is a periplasmic chaperone that assists the folding and insertion of many OMPs, including OmpA, a model OMP with a membrane embedded β-barrel domain and a periplasmic αβ domain. Structurally, Skp belongs to a family of cavity-containing chaperones that bind their substrates in the cavity, protecting them from aggregation. However, some substrates, such as OmpA, exceed the capacity of the chaperone cavity, posing a mechanistic challenge. Here, we provide direct NMR evidence that, while bound to Skp, the β-barrel domain of OmpA is maintained in an unfolded state, whereas the periplasmic domain is folded in its native conformation. Complementary cross-linking and NMR relaxation experiments show that the OmpA β-barrel is bound deep within the Skp cavity, whereas the folded periplasmic domain protrudes outside of the cavity where it tumbles independently from the rest of the complex. This domain-based chaperoning mechanism allows the transport of β-barrels across the periplasm in an unfolded state, which may be important for efficient insertion into the outer membrane." @default.
• W2037842354 created "2016-06-24" @default.
• W2037842354 creator A5008236945 @default.
• W2037842354 creator A5019429880 @default.
• W2037842354 creator A5042967209 @default.
• W2037842354 creator A5053398061 @default.
• W2037842354 creator A5089423741 @default.
• W2037842354 date "2009-02-10" @default.
• W2037842354 modified "2023-10-17" @default.
• W2037842354 title "The cavity-chaperone Skp protects its substrate from aggregation but allows independent folding of substrate domains" @default.
• W2037842354 cites W1482770146 @default.
• W2037842354 cites W1529158977 @default.
• W2037842354 cites W1937307250 @default.
• W2037842354 cites W1965072402 @default.
• W2037842354 cites W1968977176 @default.
• W2037842354 cites W1975465001 @default.
• W2037842354 cites W1977190262 @default.
• W2037842354 cites W1980858544 @default.
• W2037842354 cites W1988367050 @default.
• W2037842354 cites W1993077659 @default.
• W2037842354 cites W2004945980 @default.
• W2037842354 cites W2007363410 @default.
• W2037842354 cites W2017875807 @default.
• W2037842354 cites W2019381852 @default.
• W2037842354 cites W2029086579 @default.
• W2037842354 cites W2035250546 @default.
• W2037842354 cites W2040062153 @default.
• W2037842354 cites W2046177551 @default.
• W2037842354 cites W2055341880 @default.
• W2037842354 cites W2055399080 @default.
• W2037842354 cites W2057576135 @default.
• W2037842354 cites W2059784037 @default.
• W2037842354 cites W2061093994 @default.
• W2037842354 cites W2061379882 @default.
• W2037842354 cites W2062404215 @default.
• W2037842354 cites W2074654002 @default.
• W2037842354 cites W2078793166 @default.
• W2037842354 cites W2079021559 @default.
• W2037842354 cites W2079472529 @default.
• W2037842354 cites W2081717721 @default.
• W2037842354 cites W2081866213 @default.
• W2037842354 cites W2106125326 @default.
• W2037842354 cites W2107217578 @default.
• W2037842354 cites W2110239496 @default.
• W2037842354 cites W2116811320 @default.
• W2037842354 cites W2118991108 @default.
• W2037842354 cites W2121963790 @default.
• W2037842354 cites W2123067651 @default.
• W2037842354 cites W2129272296 @default.
• W2037842354 cites W2129879061 @default.
• W2037842354 cites W2129925452 @default.
• W2037842354 cites W2141375922 @default.
• W2037842354 cites W2144338701 @default.
• W2037842354 cites W2147281292 @default.
• W2037842354 cites W2153932901 @default.
• W2037842354 cites W2156031091 @default.
• W2037842354 cites W2168117947 @default.
• W2037842354 cites W2169769186 @default.
• W2037842354 cites W2169821755 @default.
• W2037842354 cites W2615823793 @default.
• W2037842354 doi "https://doi.org/10.1073/pnas.0809275106" @default.
• W2037842354 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2644113" @default.
• W2037842354 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19181847" @default.
• W2037842354 hasPublicationYear "2009" @default.
• W2037842354 type Work @default.
• W2037842354 sameAs 2037842354 @default.
• W2037842354 citedByCount "120" @default.
• W2037842354 countsByYear W20378423542012 @default.
• W2037842354 countsByYear W20378423542013 @default.
• W2037842354 countsByYear W20378423542014 @default.
• W2037842354 countsByYear W20378423542015 @default.
• W2037842354 countsByYear W20378423542016 @default.
• W2037842354 countsByYear W20378423542017 @default.
• W2037842354 countsByYear W20378423542018 @default.
• W2037842354 countsByYear W20378423542019 @default.
• W2037842354 countsByYear W20378423542020 @default.
• W2037842354 countsByYear W20378423542021 @default.
• W2037842354 countsByYear W20378423542022 @default.
• W2037842354 countsByYear W20378423542023 @default.
• W2037842354 crossrefType "journal-article" @default.
• W2037842354 hasAuthorship W2037842354A5008236945 @default.
• W2037842354 hasAuthorship W2037842354A5019429880 @default.
• W2037842354 hasAuthorship W2037842354A5042967209 @default.
• W2037842354 hasAuthorship W2037842354A5053398061 @default.
• W2037842354 hasAuthorship W2037842354A5089423741 @default.
• W2037842354 hasBestOaLocation W20378423541 @default.
• W2037842354 hasConcept C104317684 @default.
• W2037842354 hasConcept C119599485 @default.
• W2037842354 hasConcept C12554922 @default.
• W2037842354 hasConcept C127413603 @default.
• W2037842354 hasConcept C130316041 @default.
• W2037842354 hasConcept C142724271 @default.
• W2037842354 hasConcept C146587185 @default.
• W2037842354 hasConcept C185592680 @default.
• W2037842354 hasConcept C201663137 @default.
• W2037842354 hasConcept C204328495 @default.
• W2037842354 hasConcept C2775962898 @default.
• W2037842354 hasConcept C2776545253 @default.

• next