Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037854977> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2037854977 endingPage "500" @default.
- W2037854977 startingPage "491" @default.
- W2037854977 abstract "Novel therapeutic strategies utilizing plasmid DNA (pDNA) have been sought for non-treatable neurological disorders, such as ischemic stroke, Parkinson disease (PD), Alzheimer disease (AD), and multiple sclerosis (MS). One strategy is to induce overexpression of growth factors, such as vascular endothelial growth factor (VEGF), glial cell-line derived neurotrophic factor (GDNF), and hepatocyte growth factor (HGF), in the brain. Since ischemic stroke, PD, and AD show damage of neurons, the transfer of pDNA encoding these genes has been examined and shown to protect neurons from damage, associated with a better behavioral outcome. These growth factors have also been shown to accelerate angiogenesis, neurite outgrowth, and neurogenesis in the brain, and overexpression of these factors showed therapeutic effects in cerebral ischemia in rodents. Another application of pDNA is as a “DNA vaccine” to induce immunity against amyloid Aβ in AD, which requires a predominantly Th2 response to avoid autoimmune encephalomyelitis evoked by a Th1 response. Since the combination of pDNA and special devices and/or modification of pDNA could induce a predominantly Th2 response to a targeted antigen, a pDNA-based vaccine would be ideal for AD. Interestingly, pDNA could also induce immune tolerance, and pDNA-based vaccines to induce immune tolerance to autoimmune antibodies have been extensively examined in an animal model of MS. Based on the results, a pDNA vaccine has already been tried in MS patients and reported to be safe and partly effective in phase I/II clinical studies. In this review, we discuss the potential and problems of pDNA-mediated medicine in neurological disorders. Keywords: Plasmid DNA, cerebral ischemia, Parkinson disease, Alzheimer diseasek, multiple sclerosis, DNA vaccine" @default.
- W2037854977 created "2016-06-24" @default.
- W2037854977 creator A5025005882 @default.
- W2037854977 creator A5043476878 @default.
- W2037854977 creator A5068120492 @default.
- W2037854977 date "2011-12-01" @default.
- W2037854977 modified "2023-09-23" @default.
- W2037854977 title "Experimental and Clinical Application of Plasmid DNA in the Field of Central Nervous Diseases" @default.
- W2037854977 doi "https://doi.org/10.2174/156652311798192833" @default.
- W2037854977 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22023479" @default.
- W2037854977 hasPublicationYear "2011" @default.
- W2037854977 type Work @default.
- W2037854977 sameAs 2037854977 @default.
- W2037854977 citedByCount "26" @default.
- W2037854977 countsByYear W20378549772012 @default.
- W2037854977 countsByYear W20378549772013 @default.
- W2037854977 countsByYear W20378549772014 @default.
- W2037854977 countsByYear W20378549772015 @default.
- W2037854977 countsByYear W20378549772016 @default.
- W2037854977 countsByYear W20378549772017 @default.
- W2037854977 countsByYear W20378549772019 @default.
- W2037854977 countsByYear W20378549772020 @default.
- W2037854977 countsByYear W20378549772022 @default.
- W2037854977 crossrefType "journal-article" @default.
- W2037854977 hasAuthorship W2037854977A5025005882 @default.
- W2037854977 hasAuthorship W2037854977A5043476878 @default.
- W2037854977 hasAuthorship W2037854977A5068120492 @default.
- W2037854977 hasConcept C126322002 @default.
- W2037854977 hasConcept C160539049 @default.
- W2037854977 hasConcept C167508917 @default.
- W2037854977 hasConcept C167734588 @default.
- W2037854977 hasConcept C170493617 @default.
- W2037854977 hasConcept C185856081 @default.
- W2037854977 hasConcept C201934248 @default.
- W2037854977 hasConcept C203014093 @default.
- W2037854977 hasConcept C2776914184 @default.
- W2037854977 hasConcept C2777025900 @default.
- W2037854977 hasConcept C2778486448 @default.
- W2037854977 hasConcept C2779830541 @default.
- W2037854977 hasConcept C2780394083 @default.
- W2037854977 hasConcept C2780640218 @default.
- W2037854977 hasConcept C2780801004 @default.
- W2037854977 hasConcept C4746552 @default.
- W2037854977 hasConcept C502942594 @default.
- W2037854977 hasConcept C71924100 @default.
- W2037854977 hasConcept C86803240 @default.
- W2037854977 hasConcept C8891405 @default.
- W2037854977 hasConcept C95444343 @default.
- W2037854977 hasConceptScore W2037854977C126322002 @default.
- W2037854977 hasConceptScore W2037854977C160539049 @default.
- W2037854977 hasConceptScore W2037854977C167508917 @default.
- W2037854977 hasConceptScore W2037854977C167734588 @default.
- W2037854977 hasConceptScore W2037854977C170493617 @default.
- W2037854977 hasConceptScore W2037854977C185856081 @default.
- W2037854977 hasConceptScore W2037854977C201934248 @default.
- W2037854977 hasConceptScore W2037854977C203014093 @default.
- W2037854977 hasConceptScore W2037854977C2776914184 @default.
- W2037854977 hasConceptScore W2037854977C2777025900 @default.
- W2037854977 hasConceptScore W2037854977C2778486448 @default.
- W2037854977 hasConceptScore W2037854977C2779830541 @default.
- W2037854977 hasConceptScore W2037854977C2780394083 @default.
- W2037854977 hasConceptScore W2037854977C2780640218 @default.
- W2037854977 hasConceptScore W2037854977C2780801004 @default.
- W2037854977 hasConceptScore W2037854977C4746552 @default.
- W2037854977 hasConceptScore W2037854977C502942594 @default.
- W2037854977 hasConceptScore W2037854977C71924100 @default.
- W2037854977 hasConceptScore W2037854977C86803240 @default.
- W2037854977 hasConceptScore W2037854977C8891405 @default.
- W2037854977 hasConceptScore W2037854977C95444343 @default.
- W2037854977 hasIssue "6" @default.
- W2037854977 hasLocation W20378549771 @default.
- W2037854977 hasLocation W20378549772 @default.
- W2037854977 hasOpenAccess W2037854977 @default.
- W2037854977 hasPrimaryLocation W20378549771 @default.
- W2037854977 hasRelatedWork W1998476386 @default.
- W2037854977 hasRelatedWork W2016413004 @default.
- W2037854977 hasRelatedWork W2019475350 @default.
- W2037854977 hasRelatedWork W2020949259 @default.
- W2037854977 hasRelatedWork W2037854977 @default.
- W2037854977 hasRelatedWork W2046029159 @default.
- W2037854977 hasRelatedWork W2093484882 @default.
- W2037854977 hasRelatedWork W2511773065 @default.
- W2037854977 hasRelatedWork W2517675247 @default.
- W2037854977 hasRelatedWork W2914731970 @default.
- W2037854977 hasVolume "11" @default.
- W2037854977 isParatext "false" @default.
- W2037854977 isRetracted "false" @default.
- W2037854977 magId "2037854977" @default.
- W2037854977 workType "article" @default.