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• W2037857670 abstract "Some new cephem derivatives of types 4 and 5, viewed as analogues of type I esters in which the atomic sequence of the C-2 ester group is formally inverted, were synthesised and tested in vitro for their inhibitory activity towards human leukocyte elastase and porcine pancreatic elastase. An examination of the inhibition data obtained for the new type 4 and 5 derivatives, while exhibiting a considerable reduction in their activity against porcine pancreatic elastase, indicated that these compounds still maintain an appreciable inhibitory activity against human leukocyte elastase. On this basis the new type of C-2 substitution appears to contribute to the research of new, potentially interesting, cephalosporinic human leukocyte elastase inhibitors." @default.
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• W2037857670 date "2001-02-01" @default.
• W2037857670 modified "2023-09-27" @default.
• W2037857670 title "Synthesis and inhibitory activity towards human leukocyte elastase of new 7α-methoxy and 7α-chloro (2-acyloxymethyl) cephem derivatives" @default.
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• W2037857670 doi "https://doi.org/10.1016/s0223-5234(01)01211-9" @default.
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