Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037857730> ?p ?o ?g. }
- W2037857730 endingPage "1118" @default.
- W2037857730 startingPage "1098" @default.
- W2037857730 abstract "Significance: Hepatic ischemia/reperfusion (I/R) injury is an inevitable side effect of major liver surgery that can culminate in liver failure. The bulk of I/R-induced liver injury results from an overproduction of reactive oxygen and nitrogen species (ROS/RNS), which inflict both parenchymal and microcirculatory damage. A structure that is particularly prone to oxidative attack and modification is the glycocalyx (GCX), a meshwork of proteoglycans and glycosaminoglycans (GAGs) that covers the lumenal endothelial surface and safeguards microvascular homeostasis. ROS/RNS-mediated degradation of the GCX may exacerbate I/R injury by, for example, inducing vasoconstriction, facilitating leukocyte adherence, and directly activating innate immune cells. Recent Advances: Preliminary experiments revealed that hepatic sinusoids contain a functional GCX that is damaged during murine hepatic I/R and major liver surgery in patients. There are three ROS that mediate GCX degradation: hydroxyl radicals, carbonate radical anions, and hypochlorous acid (HOCl). HOCl converts GAGs in the GCX to GAG chloramides that become site-specific targets for oxidizing and reducing species and are more efficiently fragmented than the parent molecules. In addition to ROS/RNS, the GAG-degrading enzyme heparanase acts at the endothelial surface to shed the GCX. Critical Issues: The GCX seems to be degraded during major liver surgery, but the underlying cause remains ill-defined. Future Directions: The relative contribution of the different ROS and RNS intermediates to GCX degradation in vivo, the immunogenic potential of the shed GCX fragments, and the role of heparanase in liver I/R injury all warrant further investigation. Antioxid. Redox Signal. 21, 1098–1118." @default.
- W2037857730 created "2016-06-24" @default.
- W2037857730 creator A5025706577 @default.
- W2037857730 creator A5032072489 @default.
- W2037857730 creator A5037661266 @default.
- W2037857730 creator A5039369677 @default.
- W2037857730 creator A5052059898 @default.
- W2037857730 creator A5055466650 @default.
- W2037857730 creator A5055964450 @default.
- W2037857730 creator A5072800977 @default.
- W2037857730 creator A5078824354 @default.
- W2037857730 date "2014-09-01" @default.
- W2037857730 modified "2023-10-18" @default.
- W2037857730 title "The Mechanisms and Physiological Relevance of Glycocalyx Degradation in Hepatic Ischemia/Reperfusion Injury" @default.
- W2037857730 cites W1485321383 @default.
- W2037857730 cites W1488196937 @default.
- W2037857730 cites W1490917921 @default.
- W2037857730 cites W1491748226 @default.
- W2037857730 cites W1517866567 @default.
- W2037857730 cites W1526312778 @default.
- W2037857730 cites W1533387869 @default.
- W2037857730 cites W1537971445 @default.
- W2037857730 cites W1672954108 @default.
- W2037857730 cites W1758202367 @default.
- W2037857730 cites W1774353915 @default.
- W2037857730 cites W1813065730 @default.
- W2037857730 cites W1870329425 @default.
- W2037857730 cites W1963579419 @default.
- W2037857730 cites W1963673162 @default.
- W2037857730 cites W1966081714 @default.
- W2037857730 cites W1966420327 @default.
- W2037857730 cites W1968528145 @default.
- W2037857730 cites W1970638752 @default.
- W2037857730 cites W1971435128 @default.
- W2037857730 cites W1973313407 @default.
- W2037857730 cites W1974997758 @default.
- W2037857730 cites W1975665532 @default.
- W2037857730 cites W1976428700 @default.
- W2037857730 cites W1977556482 @default.
- W2037857730 cites W1977877980 @default.
- W2037857730 cites W1979486625 @default.
- W2037857730 cites W1980734840 @default.
- W2037857730 cites W1981211816 @default.
- W2037857730 cites W1982287005 @default.
- W2037857730 cites W1986340583 @default.
- W2037857730 cites W1986727315 @default.
- W2037857730 cites W1988760595 @default.
- W2037857730 cites W1989676517 @default.
- W2037857730 cites W1991376496 @default.
- W2037857730 cites W1991952977 @default.
- W2037857730 cites W1993686233 @default.
- W2037857730 cites W1993795415 @default.
- W2037857730 cites W1994365742 @default.
- W2037857730 cites W1995764292 @default.
- W2037857730 cites W1996795546 @default.
- W2037857730 cites W1999282267 @default.
- W2037857730 cites W2000394721 @default.
- W2037857730 cites W2001800923 @default.
- W2037857730 cites W2002473728 @default.
- W2037857730 cites W2003455033 @default.
- W2037857730 cites W2003870922 @default.
- W2037857730 cites W2004283265 @default.
- W2037857730 cites W2005774765 @default.
- W2037857730 cites W2006721421 @default.
- W2037857730 cites W2007045655 @default.
- W2037857730 cites W2008680254 @default.
- W2037857730 cites W2011229547 @default.
- W2037857730 cites W201201356 @default.
- W2037857730 cites W2015854329 @default.
- W2037857730 cites W2016324838 @default.
- W2037857730 cites W2019074842 @default.
- W2037857730 cites W2020732104 @default.
- W2037857730 cites W2020990593 @default.
- W2037857730 cites W2023868278 @default.
- W2037857730 cites W2025694904 @default.
- W2037857730 cites W2026425756 @default.
- W2037857730 cites W2027245158 @default.
- W2037857730 cites W2029017812 @default.
- W2037857730 cites W2030654802 @default.
- W2037857730 cites W2030678863 @default.
- W2037857730 cites W2030817463 @default.
- W2037857730 cites W2030967651 @default.
- W2037857730 cites W2034908043 @default.
- W2037857730 cites W2037190876 @default.
- W2037857730 cites W2040242558 @default.
- W2037857730 cites W2041402726 @default.
- W2037857730 cites W2042378588 @default.
- W2037857730 cites W2044474988 @default.
- W2037857730 cites W2044592960 @default.
- W2037857730 cites W2045969462 @default.
- W2037857730 cites W2046394334 @default.
- W2037857730 cites W2047354583 @default.
- W2037857730 cites W2049285362 @default.
- W2037857730 cites W2051875850 @default.
- W2037857730 cites W2054282976 @default.
- W2037857730 cites W2054295432 @default.
- W2037857730 cites W2054426809 @default.
- W2037857730 cites W2054512362 @default.