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- W2037863411 abstract "La hepatitis crónica por el virus de la hepatitis C afecta a casi 180 millones de personas en el mundo. La infección por el virus de la hepatitis C es curable. Hasta hace 1 año, el único tratamiento de la hepatitis por virus de la hepatitis C genotipo 1 consistía en la combinación de interferón pegilado y ribavirina con una modesta eficacia (40–50%). La llegada de los nuevos agentes antivirales directos, como el telaprevir, ha supuesto una auténtica revolución en la terapia de esta infección, un cambio de paradigma. Supone un incremento en las probabilidades de respuesta (80%) y la posibilidad de reducir la duración del tratamiento en más de la mitad de los pacientes. Se han desarrollado nuevas reglas de parada del tratamiento con el fin de evitar el desarrollo de resistencias. Finalmente, debemos prestar atención al desarrollo de efectos secundarios potencialmente graves, en especial la anemia y las alteraciones cutáneas. Chronic hepatitis due to the hepatitis C virus (HCV) infection affects nearly 180 million people worldwide. This infection is curable. Until 1 year ago, the only treatment for genotype 1 HCV was the combination of pegylated interferon and ribavirin, which was only moderately effective (40–50%). The introduction of new antiviral agents, such as telaprevir, represents a change of paradigm and has revolutionized the treatment of this infection. This drug has increased the likelihood of viral response (to 80%) and has allowed treatment length to be shortened in more than 50% of patients. New stopping rules have been developed to avoid the development of resistances. Finally, special attention should be paid to potentially serious adverse effects, particularly anemia and cutaneous alterations." @default.
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- W2037863411 date "2013-07-01" @default.
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- W2037863411 title "Telaprevir en el paciente monoinfectado sin tratamiento previo" @default.
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- W2037863411 doi "https://doi.org/10.1016/s0213-005x(13)70118-6" @default.
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