FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037869266> ?p ?o ?g. }

• W2037869266 endingPage "7731" @default.
• W2037869266 startingPage "7723" @default.
• W2037869266 abstract "The present work aimed at exploring a series of diversely 4-arylthiourea-substituted R/S-3,4-dihydro-2,2-dimethyl-6-halo-2H-1-benzopyrans structurally related to (±)-cromakalim. These new compounds were examined in vitro as putative potassium channel openers (PCOs) on rat pancreatic islets (inhibition of insulin release) as well as on rat aorta rings (relaxation of aorta ring) and their activity was compared to that of the reference KATP channel activators (±)-cromakalim, (±)-pinacidil, diazoxide and of previously reported cromakalim analogues. Structure–activity relationships indicated that the most pronounced inhibitory activity on the insulin secretory process was obtained with molecules bearing a strong meta- or para-electron-withdrawing group (CN or NO2) on the phenyl ring of the arylthiourea moiety at the 4-position of the benzopyran nucleus (compounds 12–23). Among those, R/S-6-chloro-4-(4-cyanophenylaminothiocarbonylamino)-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran (16) was found to be the most potent benzopyran-type inhibitor of insulin release ever described. Most of these original benzopyran derivatives show increased selectivity for pancreatic versus vascular tissue. Radioisotopic investigations indicated that these new compounds activated pancreatic KATP channels." @default.
• W2037869266 created "2016-06-24" @default.
• W2037869266 creator A5002425064 @default.
• W2037869266 creator A5040689564 @default.
• W2037869266 creator A5047806170 @default.
• W2037869266 creator A5059166590 @default.
• W2037869266 creator A5087763748 @default.
• W2037869266 date "2009-11-01" @default.
• W2037869266 modified "2023-10-11" @default.
• W2037869266 title "New R/S-3,4-dihydro-2,2-dimethyl-2H-1-benzopyrans as KATP channel openers: Modulation of the 4-position" @default.
• W2037869266 cites W1571734887 @default.
• W2037869266 cites W1985713312 @default.
• W2037869266 cites W1990845205 @default.
• W2037869266 cites W1992045485 @default.
• W2037869266 cites W1995589371 @default.
• W2037869266 cites W2007935184 @default.
• W2037869266 cites W2014987616 @default.
• W2037869266 cites W2018566925 @default.
• W2037869266 cites W2018869761 @default.
• W2037869266 cites W2033323300 @default.
• W2037869266 cites W2033349405 @default.
• W2037869266 cites W2038353863 @default.
• W2037869266 cites W2039969107 @default.
• W2037869266 cites W2045141639 @default.
• W2037869266 cites W2046326563 @default.
• W2037869266 cites W2060543750 @default.
• W2037869266 cites W2064775264 @default.
• W2037869266 cites W2068992335 @default.
• W2037869266 cites W2073985318 @default.
• W2037869266 cites W2074005328 @default.
• W2037869266 cites W2075393822 @default.
• W2037869266 cites W2083584165 @default.
• W2037869266 cites W2088926440 @default.
• W2037869266 cites W2095801190 @default.
• W2037869266 cites W2139404258 @default.
• W2037869266 cites W2148959338 @default.
• W2037869266 cites W2154584009 @default.
• W2037869266 cites W2155707968 @default.
• W2037869266 cites W2160723322 @default.
• W2037869266 cites W2208036780 @default.
• W2037869266 cites W276600155 @default.
• W2037869266 cites W4241128721 @default.
• W2037869266 cites W4250622522 @default.
• W2037869266 cites W4255711202 @default.
• W2037869266 doi "https://doi.org/10.1016/j.bmc.2009.09.041" @default.
• W2037869266 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19822435" @default.
• W2037869266 hasPublicationYear "2009" @default.
• W2037869266 type Work @default.
• W2037869266 sameAs 2037869266 @default.
• W2037869266 citedByCount "19" @default.
• W2037869266 countsByYear W20378692662012 @default.
• W2037869266 countsByYear W20378692662013 @default.
• W2037869266 countsByYear W20378692662014 @default.
• W2037869266 countsByYear W20378692662015 @default.
• W2037869266 countsByYear W20378692662016 @default.
• W2037869266 countsByYear W20378692662017 @default.
• W2037869266 countsByYear W20378692662018 @default.
• W2037869266 countsByYear W20378692662019 @default.
• W2037869266 countsByYear W20378692662022 @default.
• W2037869266 crossrefType "journal-article" @default.
• W2037869266 hasAuthorship W2037869266A5002425064 @default.
• W2037869266 hasAuthorship W2037869266A5040689564 @default.
• W2037869266 hasAuthorship W2037869266A5047806170 @default.
• W2037869266 hasAuthorship W2037869266A5059166590 @default.
• W2037869266 hasAuthorship W2037869266A5087763748 @default.
• W2037869266 hasConcept C126322002 @default.
• W2037869266 hasConcept C134018914 @default.
• W2037869266 hasConcept C170493617 @default.
• W2037869266 hasConcept C178790620 @default.
• W2037869266 hasConcept C185592680 @default.
• W2037869266 hasConcept C2775984225 @default.
• W2037869266 hasConcept C2776286485 @default.
• W2037869266 hasConcept C2777194220 @default.
• W2037869266 hasConcept C2778938600 @default.
• W2037869266 hasConcept C2779306644 @default.
• W2037869266 hasConcept C2779768347 @default.
• W2037869266 hasConcept C2779872217 @default.
• W2037869266 hasConcept C2780561956 @default.
• W2037869266 hasConcept C2908743524 @default.
• W2037869266 hasConcept C517785266 @default.
• W2037869266 hasConcept C55493867 @default.
• W2037869266 hasConcept C555293320 @default.
• W2037869266 hasConcept C71240020 @default.
• W2037869266 hasConcept C71924100 @default.
• W2037869266 hasConcept C83743174 @default.
• W2037869266 hasConcept C98274493 @default.
• W2037869266 hasConceptScore W2037869266C126322002 @default.
• W2037869266 hasConceptScore W2037869266C134018914 @default.
• W2037869266 hasConceptScore W2037869266C170493617 @default.
• W2037869266 hasConceptScore W2037869266C178790620 @default.
• W2037869266 hasConceptScore W2037869266C185592680 @default.
• W2037869266 hasConceptScore W2037869266C2775984225 @default.
• W2037869266 hasConceptScore W2037869266C2776286485 @default.
• W2037869266 hasConceptScore W2037869266C2777194220 @default.
• W2037869266 hasConceptScore W2037869266C2778938600 @default.
• W2037869266 hasConceptScore W2037869266C2779306644 @default.
• W2037869266 hasConceptScore W2037869266C2779768347 @default.
• W2037869266 hasConceptScore W2037869266C2779872217 @default.

• next