Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037882502> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2037882502 endingPage "35" @default.
- W2037882502 startingPage "31" @default.
- W2037882502 abstract "The partition coefficients (log P) of theoretically possible alkyliodinated iminodiacetic acid (IDA) derivatives and commercial IDA derivatives were calculated using two computer programs: ChemSketch Log P and ChemOffice Ultra. Newly synthesized ligands (DIETHYLIODIDA and DIISOPROPYLIODIDA) with the highest calculated log P were labeled with technetium-99m. The biodistribution and the influence of bilirubin on their biokinetics were investigated in rats and compared to corresponding results for commercial (99m)Tc-BROMIDA. Log P of (99m)Tc-complexes of synthesized ligands were determined experimentally as well as the protein binding. In comparison to (99m)Tc-BROMIDA, (99m)Tc-DIETHYLIODIDA has: (a) better biliary excretion (2.76±0.15%ID/g versus 1.83±0.10%ID/g); (b) faster hepatic clearance (2.90±0.21%ID/g versus 7.47±0.70%ID/g) and decreased biliary excretion (for 14% versus 22%) in conditions of hyperbilirubinemia after 15min. It is proved that (99m)Tc-DIISOPROPYLIODIDA has a prolonged hepatic transit time and decreased biliary excretion." @default.
- W2037882502 created "2016-06-24" @default.
- W2037882502 creator A5013843920 @default.
- W2037882502 creator A5022571384 @default.
- W2037882502 creator A5038401838 @default.
- W2037882502 creator A5050444110 @default.
- W2037882502 creator A5087399029 @default.
- W2037882502 creator A5090331557 @default.
- W2037882502 date "2013-04-01" @default.
- W2037882502 modified "2023-10-16" @default.
- W2037882502 title "The effect of lipophilicity on the hepatobiliary properties of iminodiacetic acid derivatives in the conditions of hyperbilirubinemia" @default.
- W2037882502 cites W1790243442 @default.
- W2037882502 cites W1848419839 @default.
- W2037882502 cites W1860485116 @default.
- W2037882502 cites W1967944009 @default.
- W2037882502 cites W199589706 @default.
- W2037882502 cites W1999689258 @default.
- W2037882502 cites W2012721995 @default.
- W2037882502 cites W2020926818 @default.
- W2037882502 cites W2024270927 @default.
- W2037882502 cites W2048312836 @default.
- W2037882502 cites W2051740372 @default.
- W2037882502 cites W2056127222 @default.
- W2037882502 cites W2088284942 @default.
- W2037882502 cites W2104403324 @default.
- W2037882502 cites W2144482822 @default.
- W2037882502 cites W2151331829 @default.
- W2037882502 cites W2164937372 @default.
- W2037882502 cites W2326023265 @default.
- W2037882502 cites W2344748167 @default.
- W2037882502 doi "https://doi.org/10.1016/j.apradiso.2012.12.014" @default.
- W2037882502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23353095" @default.
- W2037882502 hasPublicationYear "2013" @default.
- W2037882502 type Work @default.
- W2037882502 sameAs 2037882502 @default.
- W2037882502 citedByCount "3" @default.
- W2037882502 countsByYear W20378825022015 @default.
- W2037882502 countsByYear W20378825022017 @default.
- W2037882502 countsByYear W20378825022018 @default.
- W2037882502 crossrefType "journal-article" @default.
- W2037882502 hasAuthorship W2037882502A5013843920 @default.
- W2037882502 hasAuthorship W2037882502A5022571384 @default.
- W2037882502 hasAuthorship W2037882502A5038401838 @default.
- W2037882502 hasAuthorship W2037882502A5050444110 @default.
- W2037882502 hasAuthorship W2037882502A5087399029 @default.
- W2037882502 hasAuthorship W2037882502A5090331557 @default.
- W2037882502 hasConcept C10146269 @default.
- W2037882502 hasConcept C126322002 @default.
- W2037882502 hasConcept C179104552 @default.
- W2037882502 hasConcept C185592680 @default.
- W2037882502 hasConcept C192552737 @default.
- W2037882502 hasConcept C197404232 @default.
- W2037882502 hasConcept C201399114 @default.
- W2037882502 hasConcept C202751555 @default.
- W2037882502 hasConcept C2775982439 @default.
- W2037882502 hasConcept C2777513400 @default.
- W2037882502 hasConcept C2777807558 @default.
- W2037882502 hasConcept C2781137352 @default.
- W2037882502 hasConcept C43617362 @default.
- W2037882502 hasConcept C55493867 @default.
- W2037882502 hasConcept C71240020 @default.
- W2037882502 hasConcept C71924100 @default.
- W2037882502 hasConceptScore W2037882502C10146269 @default.
- W2037882502 hasConceptScore W2037882502C126322002 @default.
- W2037882502 hasConceptScore W2037882502C179104552 @default.
- W2037882502 hasConceptScore W2037882502C185592680 @default.
- W2037882502 hasConceptScore W2037882502C192552737 @default.
- W2037882502 hasConceptScore W2037882502C197404232 @default.
- W2037882502 hasConceptScore W2037882502C201399114 @default.
- W2037882502 hasConceptScore W2037882502C202751555 @default.
- W2037882502 hasConceptScore W2037882502C2775982439 @default.
- W2037882502 hasConceptScore W2037882502C2777513400 @default.
- W2037882502 hasConceptScore W2037882502C2777807558 @default.
- W2037882502 hasConceptScore W2037882502C2781137352 @default.
- W2037882502 hasConceptScore W2037882502C43617362 @default.
- W2037882502 hasConceptScore W2037882502C55493867 @default.
- W2037882502 hasConceptScore W2037882502C71240020 @default.
- W2037882502 hasConceptScore W2037882502C71924100 @default.
- W2037882502 hasLocation W20378825021 @default.
- W2037882502 hasLocation W20378825022 @default.
- W2037882502 hasOpenAccess W2037882502 @default.
- W2037882502 hasPrimaryLocation W20378825021 @default.
- W2037882502 hasRelatedWork W1951169002 @default.
- W2037882502 hasRelatedWork W1975050181 @default.
- W2037882502 hasRelatedWork W1975099013 @default.
- W2037882502 hasRelatedWork W2023093327 @default.
- W2037882502 hasRelatedWork W2023397999 @default.
- W2037882502 hasRelatedWork W2037882502 @default.
- W2037882502 hasRelatedWork W2059859439 @default.
- W2037882502 hasRelatedWork W2060040830 @default.
- W2037882502 hasRelatedWork W2081987315 @default.
- W2037882502 hasRelatedWork W2286081756 @default.
- W2037882502 hasVolume "74" @default.
- W2037882502 isParatext "false" @default.
- W2037882502 isRetracted "false" @default.
- W2037882502 magId "2037882502" @default.
- W2037882502 workType "article" @default.