FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037889864> ?p ?o ?g. }

• W2037889864 endingPage "726" @default.
• W2037889864 startingPage "719" @default.
• W2037889864 abstract "A major focus in cancer research is the identification of biomarkers for early diagnosis, therapy prediction and prognosis. Hereby, validation of target proteins on clinical samples is of high importance. Tissue microarrays (TMAs) represent an essential advancement for high-throughput analysis by assembling large numbers of tissue cores with high efficacy and comparability. However, limitations along TMA construction and processing exist. In our presented study, we had to overcome several obstacles in the construction and processing of high-density breast cancer TMAs to ensure good quality sections for further research. Exemplarily, 406 breast tissue cores from formalin-fixed and paraffin embedded samples of 245 patients were placed onto three recipient paraffin blocks. Sectioning was performed using a rotary microtome with a waterfall automated transfer system. Sections were stained by immunohistochemistry and immunofluorescence for nine proteins. The number and quality of cores after sectioning and staining was counted manually for each marker. In total, 97.1 % of all cores were available after sectioning, while further 96 % of the remaining cores were evaluable after staining. Thereby, normal tissue cores were more often lost compared to tumor tissue cores. Our workflow provides a robust method for manufacturing high-density breast cancer TMAs for subsequent IHC or IF staining without significant sample loss." @default.
• W2037889864 created "2016-06-24" @default.
• W2037889864 creator A5002772999 @default.
• W2037889864 creator A5007315728 @default.
• W2037889864 creator A5038467088 @default.
• W2037889864 creator A5046460748 @default.
• W2037889864 creator A5049682010 @default.
• W2037889864 creator A5079892703 @default.
• W2037889864 creator A5083037852 @default.
• W2037889864 date "2014-03-07" @default.
• W2037889864 modified "2023-10-18" @default.
• W2037889864 title "A ‘Waterfall’ Transfer-based Workflow for Improved Quality of Tissue Microarray Construction and Processing in Breast Cancer Research" @default.
• W2037889864 cites W1967252809 @default.
• W2037889864 cites W1970097983 @default.
• W2037889864 cites W1975992715 @default.
• W2037889864 cites W1984732635 @default.
• W2037889864 cites W1993970782 @default.
• W2037889864 cites W1998412423 @default.
• W2037889864 cites W2002015711 @default.
• W2037889864 cites W2002500046 @default.
• W2037889864 cites W2016897474 @default.
• W2037889864 cites W2039762214 @default.
• W2037889864 cites W2049634718 @default.
• W2037889864 cites W2050578821 @default.
• W2037889864 cites W2060937867 @default.
• W2037889864 cites W2061651600 @default.
• W2037889864 cites W2063571129 @default.
• W2037889864 cites W2063768074 @default.
• W2037889864 cites W2087810003 @default.
• W2037889864 cites W2091372427 @default.
• W2037889864 cites W2100229771 @default.
• W2037889864 cites W2108307140 @default.
• W2037889864 cites W2111560591 @default.
• W2037889864 cites W2114965121 @default.
• W2037889864 cites W2128511537 @default.
• W2037889864 cites W2162871269 @default.
• W2037889864 cites W2165677013 @default.
• W2037889864 cites W2172090513 @default.
• W2037889864 cites W2330940713 @default.
• W2037889864 cites W2411891464 @default.
• W2037889864 cites W4247434172 @default.
• W2037889864 doi "https://doi.org/10.1007/s12253-014-9752-3" @default.
• W2037889864 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24619867" @default.
• W2037889864 hasPublicationYear "2014" @default.
• W2037889864 type Work @default.
• W2037889864 sameAs 2037889864 @default.
• W2037889864 citedByCount "8" @default.
• W2037889864 countsByYear W20378898642016 @default.
• W2037889864 countsByYear W20378898642017 @default.
• W2037889864 countsByYear W20378898642020 @default.
• W2037889864 countsByYear W20378898642021 @default.
• W2037889864 crossrefType "journal-article" @default.
• W2037889864 hasAuthorship W2037889864A5002772999 @default.
• W2037889864 hasAuthorship W2037889864A5007315728 @default.
• W2037889864 hasAuthorship W2037889864A5038467088 @default.
• W2037889864 hasAuthorship W2037889864A5046460748 @default.
• W2037889864 hasAuthorship W2037889864A5049682010 @default.
• W2037889864 hasAuthorship W2037889864A5079892703 @default.
• W2037889864 hasAuthorship W2037889864A5083037852 @default.
• W2037889864 hasConcept C121608353 @default.
• W2037889864 hasConcept C126322002 @default.
• W2037889864 hasConcept C136229726 @default.
• W2037889864 hasConcept C142724271 @default.
• W2037889864 hasConcept C177212765 @default.
• W2037889864 hasConcept C193270364 @default.
• W2037889864 hasConcept C204232928 @default.
• W2037889864 hasConcept C3020109028 @default.
• W2037889864 hasConcept C41008148 @default.
• W2037889864 hasConcept C530470458 @default.
• W2037889864 hasConcept C680638 @default.
• W2037889864 hasConcept C71924100 @default.
• W2037889864 hasConcept C74864618 @default.
• W2037889864 hasConcept C77088390 @default.
• W2037889864 hasConceptScore W2037889864C121608353 @default.
• W2037889864 hasConceptScore W2037889864C126322002 @default.
• W2037889864 hasConceptScore W2037889864C136229726 @default.
• W2037889864 hasConceptScore W2037889864C142724271 @default.
• W2037889864 hasConceptScore W2037889864C177212765 @default.
• W2037889864 hasConceptScore W2037889864C193270364 @default.
• W2037889864 hasConceptScore W2037889864C204232928 @default.
• W2037889864 hasConceptScore W2037889864C3020109028 @default.
• W2037889864 hasConceptScore W2037889864C41008148 @default.
• W2037889864 hasConceptScore W2037889864C530470458 @default.
• W2037889864 hasConceptScore W2037889864C680638 @default.
• W2037889864 hasConceptScore W2037889864C71924100 @default.
• W2037889864 hasConceptScore W2037889864C74864618 @default.
• W2037889864 hasConceptScore W2037889864C77088390 @default.
• W2037889864 hasIssue "3" @default.
• W2037889864 hasLocation W20378898641 @default.
• W2037889864 hasLocation W20378898642 @default.
• W2037889864 hasOpenAccess W2037889864 @default.
• W2037889864 hasPrimaryLocation W20378898641 @default.
• W2037889864 hasRelatedWork W1966161430 @default.
• W2037889864 hasRelatedWork W1992481203 @default.
• W2037889864 hasRelatedWork W1993946980 @default.
• W2037889864 hasRelatedWork W2013745628 @default.
• W2037889864 hasRelatedWork W2035464821 @default.
• W2037889864 hasRelatedWork W2040976599 @default.

• next