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- W2037890752 abstract "The goal of this study was to determine levels of serine proteinases and their inhibitors in serum and blister fluid of patients with pemphigus vulgaris (PV) and bullous pemphigoid (BP) in the course of treatment with prednisolone and proteinase inhibitors such as Contrycal and ε-aminocaproic acid. Assessment of the total proteolytic activity of serine proteinases (TPASP) and total antitryptic activity (TATA) is sera and blister fluids from 53 PV and 38 BP patients showed abnormalities in the proteinase and proteinase inhibitor levels in the acute stage of these bullous dermatoses. In PV, the level of TRASP was raised to 495 ± 73 mU/ml (control 246 ± 48 mU/ml; P < 0.001) in serum and to 849 ± 96 mU/ml (control 189 ± 34 mU/ml; P < 0.001) in blister fluid. In BP, the level of TPASP was raised to 472 ± 101 mU/ml (P < 0.001) and 796 ± 103 mU/ml (P < 0.001) in serum and blister fluid, respectively. In both dermatoses, the increase in serine proteinase activity developed against the background of decreased or unchanged antiproteolytic activity. TATA levels dropped to 16 ± 5 inhibitory units (iU)/ml (control 26 ± 5 iU/ml; P < 0.001) in PV serum and to 6 ± 1 iU/ml (control 20 ± 2 iU/ml: P < 0.001) in PV blister fluid. In BP, serum TATA levels were within normal values, whereas blister fluid TATA levels were significantly decreased (14 ± 3 iU/ml; P < 0.1). The most pronounced disturbances in the proteinase-proteinase inhibitor system were found in patients with the most severe forms of pemphigus and pemphigoid. The changes in the proteinase-proteinase inhibitor system returned toward normal as the diseases improved after treatment with glucocorticoids and the proteinase inhibitors. The results suggest that the levels of proteinases and proteinase inhibitors in serum and blister fluid of patients with PV and BP are abnormal. Cause and effect relationships are unclear. The increased production and decreased inactivation of tryptic-like proteinases may be reversed by treatment. Proteinase inhibitors can be used as adjuvant therapy of pemphigus and pemphigoid." @default.
- W2037890752 created "2016-06-24" @default.
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- W2037890752 date "1992-09-01" @default.
- W2037890752 modified "2023-09-27" @default.
- W2037890752 title "Decompensation in proteinase-inhibitor system and application of proteinase inhibitors in pemphigus and pemphigoid" @default.
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- W2037890752 doi "https://doi.org/10.1016/0923-1811(92)90065-j" @default.
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