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• W2037899693 abstract "ABSTRACT As a continuation of our work with SB‐277011A, we have examined the effects of another highly elective dopamine (DA) D 3 receptor antagonist, N‐(4‐[4‐{2,3‐dichlorophenyl}‐1‐piperazinyl]butyl)‐2‐fluorenylcarboxamide (NGB 2904), in animal models of addiction. Our results indicate that by systemic administration, NGB 2904 inhibits intravenous cocaine self‐administration maintained under a progressive‐ratio (PR) reinforcement schedule, cocaine‐ or cocaine cue–induced reinstatement of cocaine‐seeking behavior, and cocaine‐ or other addictive drug‐enhanced brain stimulation reward (BSR). The action of NGB 2904 on PR cocaine self‐administration was long‐lasting (1–2 days) after a single injection, supporting its potential use in treatment of cocaine addiction. The effects of NGB 2904 in the BSR paradigm were dose‐dependent for both NGB 2904 and cocaine; that is, only lower doses of NGB 2904 were effective, and their putative antiaddiction effect could be overcome by increasing the doses of cocaine or other addictive drugs. A dopamine‐dependent mechanism is proposed to explain the effects of NGB 2904 on cocaine's actions in these animal models of drug addiction. The data reviewed in this paper suggest that NGB 2904 or other D 3 ‐selective antagonists may have potential in controlling motivation for drug‐taking behavior or relapse to drug‐seeking behavior, but may have a limited role in antagonizing the acute rewarding effects produced by cocaine or other addictive drugs. In addition, NGB 2904 may also act as a useful tool to study the role of D 3 receptors in drug addiction." @default.
• W2037899693 created "2016-06-24" @default.
• W2037899693 creator A5026940576 @default.
• W2037899693 creator A5060050668 @default.
• W2037899693 date "2007-06-01" @default.
• W2037899693 modified "2023-09-26" @default.
• W2037899693 title "Pharmacological Actions of NGB 2904, a Selective Dopamine D ₃ Receptor Antagonist, in Animal Models of Drug Addiction" @default.
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• W2037899693 doi "https://doi.org/10.1111/j.1527-3458.2007.00013.x" @default.
• W2037899693 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3771110" @default.
• W2037899693 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17627675" @default.
• W2037899693 hasPublicationYear "2007" @default.
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