FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037901026> ?p ?o ?g. }

• W2037901026 endingPage "435" @default.
• W2037901026 startingPage "429" @default.
• W2037901026 abstract "The crystal structure of the anticancer drug oxaliplatin, [Pt(R,R-DACH)(oxalate)] (DACH = diaminocyclohexane), was first reported in the non-centrosymmetric space group P21, confirming the sole presence of the R,R enantiomer of the DACH ligand (Bruck et al. (1984) [5]). It was later proposed that the crystal structure is better described in the centrosymmetric space group P21/m, signifying the presence of the compound as a racemic mixture (Abu-Surrah et al. (2003) [6]). Herein is presented a reinvestigation of this crystal structure, which shows that the discrepancy between the two proposed space group assignments arises from overlooked pseudo symmetry. The crystal structures of the synthetic precursor to oxaliplatin, Pt(R,R-DACH)I2, and a platinum(IV) derivative, trans-[Pt(R,R-DACH)(oxalate)(OH)2], were also determined, and the absolute configuration of the DACH ligand in each was confirmed to be R,R. A spectroscopic investigation of the optical rotatory dispersion (ORD) of the oxaliplatin crystals was carried out to further confirm the lack of the true crystallographic mirror plane required for a P21/m solution. The ORD was theoretically simulated, in one instance, by applying the Kramers–Kronig transform to the computed circular dichroism spectrum and was found to corroborate the spectroscopic and crystallographic findings. Finally, a brief discussion is given of the importance of discussing the details of nuanced crystal structures and of providing evidence in addition to X-ray structure determination if chemically unexpected results are obtained." @default.
• W2037901026 created "2016-06-24" @default.
• W2037901026 creator A5090805594 @default.
• W2037901026 date "2014-01-01" @default.
• W2037901026 modified "2023-09-24" @default.
• W2037901026 title "The crystal structure of oxaliplatin: A case of overlooked pseudo symmetry" @default.
• W2037901026 cites W1966182479 @default.
• W2037901026 cites W1974693247 @default.
• W2037901026 cites W1975080796 @default.
• W2037901026 cites W1982626876 @default.
• W2037901026 cites W1989885406 @default.
• W2037901026 cites W2008423326 @default.
• W2037901026 cites W2025253673 @default.
• W2037901026 cites W2039293281 @default.
• W2037901026 cites W2042992985 @default.
• W2037901026 cites W2045236580 @default.
• W2037901026 cites W2051339183 @default.
• W2037901026 cites W2051703068 @default.
• W2037901026 cites W2053246850 @default.
• W2037901026 cites W2067718414 @default.
• W2037901026 cites W2067727520 @default.
• W2037901026 cites W2071278571 @default.
• W2037901026 cites W2074645979 @default.
• W2037901026 cites W2092787673 @default.
• W2037901026 cites W2105728506 @default.
• W2037901026 cites W2114312014 @default.
• W2037901026 cites W2117178895 @default.
• W2037901026 cites W2128179591 @default.
• W2037901026 cites W2130177169 @default.
• W2037901026 cites W2130810457 @default.
• W2037901026 cites W2134391977 @default.
• W2037901026 cites W2156779445 @default.
• W2037901026 cites W2166689829 @default.
• W2037901026 cites W2310586216 @default.
• W2037901026 cites W4230767300 @default.
• W2037901026 cites W4247265992 @default.
• W2037901026 doi "https://doi.org/10.1016/j.poly.2013.10.003" @default.
• W2037901026 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3885251" @default.
• W2037901026 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24415827" @default.
• W2037901026 hasPublicationYear "2014" @default.
• W2037901026 type Work @default.
• W2037901026 sameAs 2037901026 @default.
• W2037901026 citedByCount "20" @default.
• W2037901026 countsByYear W20379010262014 @default.
• W2037901026 countsByYear W20379010262015 @default.
• W2037901026 countsByYear W20379010262016 @default.
• W2037901026 countsByYear W20379010262017 @default.
• W2037901026 countsByYear W20379010262018 @default.
• W2037901026 countsByYear W20379010262019 @default.
• W2037901026 countsByYear W20379010262020 @default.
• W2037901026 countsByYear W20379010262021 @default.
• W2037901026 countsByYear W20379010262022 @default.
• W2037901026 countsByYear W20379010262023 @default.
• W2037901026 crossrefType "journal-article" @default.
• W2037901026 hasAuthorship W2037901026A5090805594 @default.
• W2037901026 hasBestOaLocation W20379010262 @default.
• W2037901026 hasConcept C106159729 @default.
• W2037901026 hasConcept C111771559 @default.
• W2037901026 hasConcept C115624301 @default.
• W2037901026 hasConcept C116569031 @default.
• W2037901026 hasConcept C162324750 @default.
• W2037901026 hasConcept C170493617 @default.
• W2037901026 hasConcept C179104552 @default.
• W2037901026 hasConcept C185592680 @default.
• W2037901026 hasConcept C199360897 @default.
• W2037901026 hasConcept C2776351790 @default.
• W2037901026 hasConcept C2778074193 @default.
• W2037901026 hasConcept C2781285689 @default.
• W2037901026 hasConcept C41008148 @default.
• W2037901026 hasConcept C486523 @default.
• W2037901026 hasConcept C55493867 @default.
• W2037901026 hasConcept C71240020 @default.
• W2037901026 hasConcept C8010536 @default.
• W2037901026 hasConceptScore W2037901026C106159729 @default.
• W2037901026 hasConceptScore W2037901026C111771559 @default.
• W2037901026 hasConceptScore W2037901026C115624301 @default.
• W2037901026 hasConceptScore W2037901026C116569031 @default.
• W2037901026 hasConceptScore W2037901026C162324750 @default.
• W2037901026 hasConceptScore W2037901026C170493617 @default.
• W2037901026 hasConceptScore W2037901026C179104552 @default.
• W2037901026 hasConceptScore W2037901026C185592680 @default.
• W2037901026 hasConceptScore W2037901026C199360897 @default.
• W2037901026 hasConceptScore W2037901026C2776351790 @default.
• W2037901026 hasConceptScore W2037901026C2778074193 @default.
• W2037901026 hasConceptScore W2037901026C2781285689 @default.
• W2037901026 hasConceptScore W2037901026C41008148 @default.
• W2037901026 hasConceptScore W2037901026C486523 @default.
• W2037901026 hasConceptScore W2037901026C55493867 @default.
• W2037901026 hasConceptScore W2037901026C71240020 @default.
• W2037901026 hasConceptScore W2037901026C8010536 @default.
• W2037901026 hasLocation W20379010261 @default.
• W2037901026 hasLocation W20379010262 @default.
• W2037901026 hasLocation W20379010263 @default.
• W2037901026 hasLocation W20379010264 @default.
• W2037901026 hasLocation W20379010265 @default.
• W2037901026 hasOpenAccess W2037901026 @default.
• W2037901026 hasPrimaryLocation W20379010261 @default.
• W2037901026 hasRelatedWork W1965256690 @default.

• next