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- W2037901380 abstract "Circulating growth hormone, insulin, C-peptide, and glucose levels were compared during the sleep state in adults with acromegaly and healthy control subjects. Growth hormone secretion was episodic in both groups, with the sleep-related growth hormone peak noticeably absent in the acromegalic subjects. The mean nocturnal plasma insulin concentration was greater in the acromegalics. There was no significant difference in the C-peptide between the two groups. Insulin and glucose levels did not show an early morning rise in either acromegalics or healthy subjects. The authors conclude that there is a marked difference in the circulating levels of growth hormone and insulin between the acromegalic and the healthy groups during the sleep state, and there is no sleep-related nocturnal growth hormone peak in the acromegalic subjects. The hyperinsulinism of patients with acromegaly cannot be attributed to excess secretion of insulin." @default.
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- W2037901380 date "1996-06-01" @default.
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- W2037901380 title "Nocturnal Monitoring of Growth Hormone, Insulin, C-Peptide, and Glucose in Patients With Acromegaly" @default.
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- W2037901380 doi "https://doi.org/10.1016/s0002-9629(15)41722-7" @default.
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