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- W2037904904 abstract "Letters15 December 1990Treatment of Cryptococcal Meningitis in AIDSRussell D. Wong, MD, Goetz Matthew B., MDRussell D. Wong, MDSearch for more papers by this author, Goetz Matthew B., MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-113-12-992_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: In their recent article, Larsen and colleagues (1) report that patients with AIDS who had acute cryptococcal meningitis responded more frequently to reatment with amphotericin B and flucytosine than to treatment with fluconazole. We believe, however, that further amplification of several points is necessary to determine the feasibility of such combination therapy in these patients and to better show the contribution of flucytosine.First, we are uncertain as to how frequently flucytosine dosing was interrupted because of the development of flucytosine toxicity; although the incidence of hepatitis, diarrhea, anemia, and thrombocytopenia is well described, there is no...References1. LarsenLealChan RML. Fluconazole compared with amphotericin plus flucytosine for cryptococcal meningitis in AIDS. Ann Intern Med. 1990;113:183-7. LinkGoogle Scholar2. ChuckSande SM. Infections with Cryptococcus neoformans in the acquired immunodeficiency syndrome. N Engl J Med. 1989;321:794-9. CrossrefMedlineGoogle Scholar3. ZugerLouieHolzman AER. Cryptococcal disease in patients with the acquired immunodeficiency syndrome. Ann Intern Med. 1986;104:234-40. LinkGoogle Scholar4. KovacsKovacsPolis JAM. Cryptococcosis in the acquired immunodeficiency syndrome. Ann Intern Med. 1985;103:533-8. LinkGoogle Scholar1. StammDiasioDismukes ARW. Toxicity of amphotericin B plus flucytosine in 194 patients with cryptococcal meningitis. Am J Med. 1987;83:236-42. CrossrefMedlineGoogle Scholar2. LarsenLealChan RML. Fluconazole compared with amphotericin B plus flucytosine for cryptococcal meningitis in AIDS. Ann Intern Med. 1990;113:183-7. LinkGoogle Scholar3. BennettDismukesDuma JWR. A comparison of amphotericin B alone and combined with flucytosine in the treatment of cryptococcal meningitis. N Engl J Med. 1979;301:126-31. CrossrefMedlineGoogle Scholar4. BozzetteLarsenChiu SRJ. Successful secondary prophylaxis of cryptococcal meningitis with fluconazole: a placebo-controlled trial. Program and Abstracts of the 30th Interscience Conference on Antimicrobial Agents and Chemotherapy, October 20-24, 1990, Atlanta, Georgia. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Sepulveda Veterans Affairs Medical Center Sepulveda, CA 91343 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 December 1990Volume 113, Issue 12Page: 992-992KeywordsAIDSAmphotericinAnemiaCryptococcal meningitisDiarrheaHepatitisToxicity Issue Published: 15 December 1990 PDF DownloadLoading ..." @default.
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- W2037904904 title "Treatment of Cryptococcal Meningitis in AIDS" @default.
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