FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037913619> ?p ?o ?g. }

• W2037913619 abstract "Although insulin is known to be an important generator of regulatory signals during fetal growth and development, neither the immediate nor long-term effects of alcohol (ethanol) on insulin action are well understood. In the rat, fetal exposure to alcohol has been shown to be correlated with a subsequent abnormal response to a glucose load in the neonate and adult. Further, fetal hypoplasia secondary to maternal alcohol consumption is correlated with decreased placental glucose transport and with a lowering of the glucose levels in fetal tissues. However, the fetal effects of alcohol cannot be completely overcome by glucose/caloric supplementation, suggesting that factors other than glucose transport are involved. Using an embryonic chick model that negates the factors of maternal/placental metabolism and transport, the current study found that fetal alcohol exposure markedly increased insulin binding in developing tissue, but had little effect on the binding of the insulin-like growth factors. Competitive binding experiments revealed a marked increase in insulin receptor numbers, but no change in binding affinity as a result of the alcohol exposure. Basal uptake of 2-deoxyglucose by fetal tissue was lowered by alcohol exposure, but incubation with exogenous porcine insulin (1 x 10(-7) M) resulted in a significant increase in glucose uptake by the alcohol-exposed embryos. The increases in insulin binding and in insulin-dependent glucose uptake notwithstanding, exogenous insulin could not induce normal levels of ornithine decarboxylase activity in embryonic cells previously exposed to alcohol.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
• W2037913619 created "2016-06-24" @default.
• W2037913619 creator A5005842531 @default.
• W2037913619 creator A5009246294 @default.
• W2037913619 creator A5015401905 @default.
• W2037913619 creator A5039571244 @default.
• W2037913619 creator A5061184086 @default.
• W2037913619 creator A5061347983 @default.
• W2037913619 creator A5070307096 @default.
• W2037913619 date "1995-06-01" @default.
• W2037913619 modified "2023-09-26" @default.
• W2037913619 title "Insulin Signaling in Chick Embryos Exposed to Alcohol" @default.
• W2037913619 cites W1531933505 @default.
• W2037913619 cites W1554485696 @default.
• W2037913619 cites W1603762978 @default.
• W2037913619 cites W1882534167 @default.
• W2037913619 cites W1964506186 @default.
• W2037913619 cites W1966522954 @default.
• W2037913619 cites W1973003994 @default.
• W2037913619 cites W1981549168 @default.
• W2037913619 cites W1985012342 @default.
• W2037913619 cites W1987877869 @default.
• W2037913619 cites W1991630897 @default.
• W2037913619 cites W1993772773 @default.
• W2037913619 cites W2005981813 @default.
• W2037913619 cites W2007796735 @default.
• W2037913619 cites W2018751358 @default.
• W2037913619 cites W2019253385 @default.
• W2037913619 cites W2028839582 @default.
• W2037913619 cites W2033214862 @default.
• W2037913619 cites W2036457593 @default.
• W2037913619 cites W2041090971 @default.
• W2037913619 cites W2049558671 @default.
• W2037913619 cites W2049800032 @default.
• W2037913619 cites W2051770482 @default.
• W2037913619 cites W2055622775 @default.
• W2037913619 cites W2059201517 @default.
• W2037913619 cites W2060481063 @default.
• W2037913619 cites W2062415677 @default.
• W2037913619 cites W2069459842 @default.
• W2037913619 cites W2073964128 @default.
• W2037913619 cites W2076840402 @default.
• W2037913619 cites W2076962597 @default.
• W2037913619 cites W2078190970 @default.
• W2037913619 cites W2080169384 @default.
• W2037913619 cites W2080613959 @default.
• W2037913619 cites W2085158587 @default.
• W2037913619 cites W2090140326 @default.
• W2037913619 cites W2101438671 @default.
• W2037913619 cites W2125398472 @default.
• W2037913619 cites W2127891186 @default.
• W2037913619 cites W2128635872 @default.
• W2037913619 cites W2137210155 @default.
• W2037913619 cites W2148156326 @default.
• W2037913619 cites W2153184710 @default.
• W2037913619 cites W2209625021 @default.
• W2037913619 cites W2327406575 @default.
• W2037913619 cites W2341471202 @default.
• W2037913619 cites W4239363807 @default.
• W2037913619 cites W89133559 @default.
• W2037913619 doi "https://doi.org/10.1111/j.1530-0277.1995.tb01570.x" @default.
• W2037913619 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7573796" @default.
• W2037913619 hasPublicationYear "1995" @default.
• W2037913619 type Work @default.
• W2037913619 sameAs 2037913619 @default.
• W2037913619 citedByCount "8" @default.
• W2037913619 countsByYear W20379136192018 @default.
• W2037913619 crossrefType "journal-article" @default.
• W2037913619 hasAuthorship W2037913619A5005842531 @default.
• W2037913619 hasAuthorship W2037913619A5009246294 @default.
• W2037913619 hasAuthorship W2037913619A5015401905 @default.
• W2037913619 hasAuthorship W2037913619A5039571244 @default.
• W2037913619 hasAuthorship W2037913619A5061184086 @default.
• W2037913619 hasAuthorship W2037913619A5061347983 @default.
• W2037913619 hasAuthorship W2037913619A5070307096 @default.
• W2037913619 hasConcept C112446052 @default.
• W2037913619 hasConcept C126322002 @default.
• W2037913619 hasConcept C134018914 @default.
• W2037913619 hasConcept C161573976 @default.
• W2037913619 hasConcept C17093226 @default.
• W2037913619 hasConcept C172680121 @default.
• W2037913619 hasConcept C196843134 @default.
• W2037913619 hasConcept C2777368190 @default.
• W2037913619 hasConcept C2777391703 @default.
• W2037913619 hasConcept C2777866211 @default.
• W2037913619 hasConcept C2779234561 @default.
• W2037913619 hasConcept C2779306644 @default.
• W2037913619 hasConcept C2780161600 @default.
• W2037913619 hasConcept C2781066024 @default.
• W2037913619 hasConcept C54355233 @default.
• W2037913619 hasConcept C55493867 @default.
• W2037913619 hasConcept C71924100 @default.
• W2037913619 hasConcept C86803240 @default.
• W2037913619 hasConcept C95444343 @default.
• W2037913619 hasConceptScore W2037913619C112446052 @default.
• W2037913619 hasConceptScore W2037913619C126322002 @default.
• W2037913619 hasConceptScore W2037913619C134018914 @default.
• W2037913619 hasConceptScore W2037913619C161573976 @default.
• W2037913619 hasConceptScore W2037913619C17093226 @default.
• W2037913619 hasConceptScore W2037913619C172680121 @default.

• next