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- W2037921808 abstract "We describe here a novel effect of activity on the subcellular distribution of NMDA receptors in hippocampal neurons in culture. In spontaneously active neurons, NMDA receptors were clustered at a few synaptic and nonsynaptic sites. Chronic blockade of NMDA receptor activity induced a 380% increase in the number of NMDA receptor clusters and a shift to a more synaptic distribution. This effect was reversible. The distributions of the presynaptic marker synaptophysin, the AMPA-type glutamate receptor subunit GluR1, and the putative NMDA receptor clustering protein PSD-95 were not affected by blockade. Regulation of the synaptic localization of NMDA receptors by activity may define a novel mechanism by which input controls a neuron's ability to modify its synapses." @default.
- W2037921808 created "2016-06-24" @default.
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- W2037921808 date "1997-10-01" @default.
- W2037921808 modified "2023-10-18" @default.
- W2037921808 title "Activity Regulates the Synaptic Localization of the NMDA Receptor in Hippocampal Neurons" @default.
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- W2037921808 doi "https://doi.org/10.1016/s0896-6273(00)80962-9" @default.
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