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- W2037935676 abstract "SUMMARY The apicomplexan parasite Toxoplasma gondii is remarkable in several aspects, since it is a protozoan that infects most nucleated cells in many warm‐blooded animals, worldwide. Although the cellular immune response against T. gondii is critical for infection control, antibodies may either enhance or block protective mechanisms, and even mediate immunological damage, directly or indirectly. Since cytokines regulate the class/subclass switch, antibodies may also be the biomarkers of protective or pathological cellular immune events. There is a scientific and clinical interest in the presence of natural and autoreactive antibodies, as well as in the ‘chronic’ immunoglobulin M (IgM) response and the post‐treatment ‘rebound’. Another interesting aspect is compartmentalization; certain immunoglobulins may uniquely be found in specific host fluids. Local synthesis has been demonstrated, but antibodies may also traverse several cell layers, like the blood–brain and haemato‐ocular barriers, and the placenta. In some instances, Fc receptors (FcRs) facilitate transport and may even have a concentrator effect, which can be related to resistance or pathology. These aspects of the humoral response against T. gondii are reviewed in the present paper." @default.
- W2037935676 created "2016-06-24" @default.
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- W2037935676 date "2007-11-27" @default.
- W2037935676 modified "2023-10-15" @default.
- W2037935676 title "Congenital and acquired toxoplasmosis: diversity and role of antibodies in different compartments of the host" @default.
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- W2037935676 doi "https://doi.org/10.1111/j.1365-3024.2007.00982.x" @default.
- W2037935676 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18042171" @default.
- W2037935676 hasPublicationYear "2007" @default.
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