FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037942255> ?p ?o ?g. }

• W2037942255 endingPage "129" @default.
• W2037942255 startingPage "121" @default.
• W2037942255 abstract "The catalytic properties of penicillin G acylase (PGA) from Escherichia coli, when used in kinetically controlled N-acylation (kcNa) of cephalosporanic nuclei, can be strongly influenced by the moiety in 3-position of the cephem structure. In the synthesis of Cefonicid (1c), the adsorption of the cephalosporanic nucleus (7-SACA) in the PGA active site appeared sensitively increased by a positive ionic interaction between an arginine (ArgA145) in the enzyme active site and the sulphonic group of the β-lactam structure. Interestingly, when PGA was immobilized on solid supports, any effect depending on the substrate structure resulted minimized; the catalytic properties of this enzyme were affected with different outcomes depending on the type of matrix and binding chemistry. The PGA immobilized on glyoxyl-agarose (hydrophilic support activated with aldehyde groups) resulted in a good catalyst when used in kinetically controlled N-acylation of different cephalosporanic nuclei. This derivatives allow much better Vs/Vh1 (defined as the ratio between the rate of synthesis and the rate of hydrolysis of the acylating agent) than the same enzyme immobilized on Eupergit C, an acrylic hydrophobic supports activated with epoxy groups. The synthetic performances of the Eupergit derivative versus different nuclei were always much poorer if compared with glyoxyl-agarose or the soluble protein. The use of PGA immobilized on glyoxyl-agarose allowed the development of efficient processes for the preparation of Cefazolin in high yield and purity. The results obtained in the optimization of this process are presented." @default.
• W2037942255 created "2016-06-24" @default.
• W2037942255 creator A5001072728 @default.
• W2037942255 creator A5007729984 @default.
• W2037942255 creator A5023708392 @default.
• W2037942255 creator A5042612943 @default.
• W2037942255 creator A5065090209 @default.
• W2037942255 creator A5066190361 @default.
• W2037942255 creator A5077558844 @default.
• W2037942255 date "2008-01-01" @default.
• W2037942255 modified "2023-10-08" @default.
• W2037942255 title "Immobilization of the acylase from Escherichia coli on glyoxyl-agarose gives efficient catalyst for the synthesis of cephalosporins" @default.
• W2037942255 cites W1520847024 @default.
• W2037942255 cites W1548718817 @default.
• W2037942255 cites W1764629353 @default.
• W2037942255 cites W1850431875 @default.
• W2037942255 cites W1965608130 @default.
• W2037942255 cites W1977733114 @default.
• W2037942255 cites W1982296302 @default.
• W2037942255 cites W1982566512 @default.
• W2037942255 cites W1985337970 @default.
• W2037942255 cites W1988478385 @default.
• W2037942255 cites W1989936388 @default.
• W2037942255 cites W1993951051 @default.
• W2037942255 cites W1998924068 @default.
• W2037942255 cites W2000703999 @default.
• W2037942255 cites W2002212415 @default.
• W2037942255 cites W2004760104 @default.
• W2037942255 cites W2009034632 @default.
• W2037942255 cites W2009940449 @default.
• W2037942255 cites W2010302762 @default.
• W2037942255 cites W2012875379 @default.
• W2037942255 cites W2021766913 @default.
• W2037942255 cites W2023899255 @default.
• W2037942255 cites W2027101973 @default.
• W2037942255 cites W2027421392 @default.
• W2037942255 cites W2034022279 @default.
• W2037942255 cites W2044430464 @default.
• W2037942255 cites W2047522536 @default.
• W2037942255 cites W2053158194 @default.
• W2037942255 cites W2064762423 @default.
• W2037942255 cites W2071951841 @default.
• W2037942255 cites W2075429395 @default.
• W2037942255 cites W2076222724 @default.
• W2037942255 cites W2076871649 @default.
• W2037942255 cites W2081815886 @default.
• W2037942255 cites W2082136403 @default.
• W2037942255 cites W2083174956 @default.
• W2037942255 cites W2085101776 @default.
• W2037942255 cites W2088619953 @default.
• W2037942255 cites W2091324881 @default.
• W2037942255 cites W2096835867 @default.
• W2037942255 cites W2099139084 @default.
• W2037942255 cites W2128829441 @default.
• W2037942255 cites W2134801170 @default.
• W2037942255 cites W2325830992 @default.
• W2037942255 cites W2407343964 @default.
• W2037942255 doi "https://doi.org/10.1016/j.enzmictec.2007.08.013" @default.
• W2037942255 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22578861" @default.
• W2037942255 hasPublicationYear "2008" @default.
• W2037942255 type Work @default.
• W2037942255 sameAs 2037942255 @default.
• W2037942255 citedByCount "28" @default.
• W2037942255 countsByYear W20379422552012 @default.
• W2037942255 countsByYear W20379422552013 @default.
• W2037942255 countsByYear W20379422552014 @default.
• W2037942255 countsByYear W20379422552015 @default.
• W2037942255 countsByYear W20379422552017 @default.
• W2037942255 countsByYear W20379422552018 @default.
• W2037942255 countsByYear W20379422552019 @default.
• W2037942255 countsByYear W20379422552020 @default.
• W2037942255 countsByYear W20379422552021 @default.
• W2037942255 countsByYear W20379422552023 @default.
• W2037942255 crossrefType "journal-article" @default.
• W2037942255 hasAuthorship W2037942255A5001072728 @default.
• W2037942255 hasAuthorship W2037942255A5007729984 @default.
• W2037942255 hasAuthorship W2037942255A5023708392 @default.
• W2037942255 hasAuthorship W2037942255A5042612943 @default.
• W2037942255 hasAuthorship W2037942255A5065090209 @default.
• W2037942255 hasAuthorship W2037942255A5066190361 @default.
• W2037942255 hasAuthorship W2037942255A5077558844 @default.
• W2037942255 hasConcept C104317684 @default.
• W2037942255 hasConcept C161790260 @default.
• W2037942255 hasConcept C178790620 @default.
• W2037942255 hasConcept C181199279 @default.
• W2037942255 hasConcept C185592680 @default.
• W2037942255 hasConcept C193557335 @default.
• W2037942255 hasConcept C21951064 @default.
• W2037942255 hasConcept C2776568683 @default.
• W2037942255 hasConcept C2778476535 @default.
• W2037942255 hasConcept C2779881004 @default.
• W2037942255 hasConcept C33633552 @default.
• W2037942255 hasConcept C43617362 @default.
• W2037942255 hasConcept C547475151 @default.
• W2037942255 hasConcept C55493867 @default.
• W2037942255 hasConcept C94412978 @default.
• W2037942255 hasConceptScore W2037942255C104317684 @default.
• W2037942255 hasConceptScore W2037942255C161790260 @default.

• next