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• W2037963721 endingPage "534" @default.
• W2037963721 startingPage "525" @default.
• W2037963721 abstract "Background & Aims: The molecular mechanisms underlying intestinal mucosal damage-repair processes induced by ischemia-reperfusion (IR) remain unknown. We determined nuclear factor–κB (NF-κB) and activator protein 1 (AP-1) activities and the expression of potential target genes relevant to damage-repair events. Methods: Rat jejunal segment was subjected to ischemia for 30 minutes followed by reperfusion for defined times. NF-κB and AP-1 activities; mucosal p105, p50, and inhibitor κB-α (IκB-α) levels; and c-fos, neurotensin, and ferritin H expression were determined by electrophoretic mobility shift assay and Western and Northern analyses, respectively. Results: NF-κB and AP-1 activities were significantly elevated from 1 to 12 hours after reperfusion. The activated NF-κB in the nuclear extract consisted of solely p50 homodimers. Activation of p50 was associated with a decrease of p105, generation of p50, and increased phosphorylation and degradation of IκB-α. The activated AP-1 contained c-fos but not c-jun, fosB, and Fra-1. Reperfusion induced a transient elevation of c-fos, prolonged increase of neurotensin, and early reduction followed by recovery of ferritin H messenger RNA. Conclusions: The intestine shows organ-specific responses to IR, characterized by prolonged NF-κB and AP-1 activation involving NF-κB p50 dimers and excluding AP-1 c-jun protein. Degradation of the IκB-γ component of p105 and partial reduction IκB-α selectively activate p50/p50 dimers. Temporal patterns of target gene expression reflect functional relevance to mucosal damage-repair processes after IR.GASTROENTEROLOGY 2000;118:525-534" @default.
• W2037963721 created "2016-06-24" @default.
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• W2037963721 date "2000-03-01" @default.
• W2037963721 modified "2023-10-18" @default.
• W2037963721 title "Rapid activation of NF-κB and AP-1 and target gene expression in postischemic rat intestine" @default.
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• W2037963721 doi "https://doi.org/10.1016/s0016-5085(00)70258-7" @default.
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