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- W2037967609 abstract "Abstract The tumor promoter, 12-0-tetradecanoyl-phorbol-13-acetate (TPA), inhibits induced differentiation of murine erythroleukemia cells (MELC). Employing MELC synchronized in the G 1 S phase of the cell cycle and placed in culture with hexamethylene bisacetamide, it is shown that TPA blocks the accumulation of globin mRNA and globin synthesis. The TPA-sensitive period for inhibition of globin synthesis persists for up to 9 hrs, a time corresponding to the transit of cells through the first S, G2, M and into G1. If addition of TPA is delayed for 11 hrs or more, there is induction of accumulation of globin mRNA and globin synthesis." @default.
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- W2037967609 date "1980-06-01" @default.
- W2037967609 modified "2023-09-27" @default.
- W2037967609 title "Inhibition of induced murine erythroleukemia cell differentiation by tumor promoters: Relation to the cell cycle" @default.
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- W2037967609 doi "https://doi.org/10.1016/0006-291x(80)91315-7" @default.
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